Current Whitehead Fellows

Brummelkamp exploits a process called RNA interference (RNAi), which can selectively turn off specific genes, to study genes implicated in cancer. He and his colleagues hope to use RNAi to identify vulnerabilities in a cancer cell’s genetic make-up that can be targeted by new therapeutics.

Hochwagen studies cell division, in particular meiosis, the process by which sperm and egg cells are created. He's interested in the surveillance mechanisms that guard against mistakes during this essential biological process, probing the mechanism by which cells repair genetic damage.

Using a synthesis of standard biological and biochemical research techniques with the experimental and theoretical tool kit of physics, Wiggins is building quantitative models of biological processes and phenomena. His work is currently focused on understanding the mechanisms that shape the physical structure of chromosomes and investigating the role of chromatin structure in gene expression.

Defne Yarar investigates how a network of proteins, called the actin cytoskeleton, contribute to and are regulated during endocytosis. In endocytosis, the outer membrane of the cell folds inward to form small compartments, entirely enclosed by membrane. This operation is involved in nutrient uptake, certain forms of cell regulation (such as turning off extracellular growth signals), immune system function and other crucial tasks. Problems in endocytosis can result in diseases, such as familial hypercholesterolemia and have been linked to cancer development.