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Cloning

Despite major technological advances in the techniques used to clone mammals, and notwithstanding the many optimistic scenarios put forward by cloning advocates, two seemingly insurmountable problems plague scientists’ attempts at mammalian cloning: Very few clones survive long enough to be born, and those that do often are grotesquely large or otherwise malformed. Researchers at Whitehead Institute have identified the root causes of many of these fundamental cloning problems in research papers over the past three years.



Video

Rudolf Jaenisch In this Director’s Lecture for Nonscientists, Whitehead Member Rudolf Jaenisch paints a clear picture of what is and is not scientifically feasible in cloning. Animal cloning used non-reproductive cells to create a carbon copy of the donor animal. This technique fails frequently and yields severe abnormalities.Consequently, Jaenisch believes the cloning of humans will never prove practical. [view video]
Whitehead Member Rudolf Jaenisch addresses the biology of human cloning as part of the presentation "Human Cloning and Human Rights: Promises and Perils." The lecture series, sponsored by the MIT Program on Human Rights and Justice, is available for viewing at MIT World. [view video]
Cloning During nuclear transfer to accomplish cloning, the nucleus from a donor cell is injected into an emptied egg. The egg resets the developmental clock of the donor nucleus and the reprogrammed cell develops into an embryo. In reproductive cloning, the embryo is implanted in the uterus. [view QuickTime video]
video: Kevin Eggan

Whitehead Feature Story

Of clones and clowns. Whitehead Member Robert Weinberg discusses the “cloning circus” and the damage it is doing to serious research. Essay appeared in The Atlantic Monthly, June 2002.

Whitehead News Stories

Cloned stem cells prove identical to fertilized stem cells (2006)
Scientists clone mice from olfactory cells (2004)
Faulty reprogramming likely culprit behind cloning failures, review finds (2003)
Scientists show cloning leads to severe dysregulation of many genes (2002)
Scientists track down the root of cloning problems (2001)

Related Links

Don't clone humans! Rudolf Jaenisch and Ian Wilmut, Science Express, March 28, 2001.
Glossary of cloning terms - Compiled by the National Academies.
Cloning - A collection of resources from MEDLINEplus, a service of the U.S. National Library of Medicine and the National Institutes of Health.
Cloning in focus - An excellent introduction to cloning from the Genetic Science Learning Center. Teacher resources covering cloning and other genetics topics also are available.
Cloning: How it works - An interactive guide to cloning with graphics and animations provided by Guardian Unlimited.
Creating a cloned sheep named dolly - General information on cloning from the National Institutes of Health Office of Science Education.
How cloning works - From the How Stuff Works Web site.
How human cloning will work - From the How Stuff Works Web site.
The science of transgenics - Scientific illustration from Whitehead's Paradigm magazine.

Last updated February 8, 2006.

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