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| Monday, April 25, 2011
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Noon - 1:00 PM
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Biolomolecular Seminar Series
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| Description: |
"Fishing for novel regulators of liver development and regeneration"
Dr. Wolfram Goessling, Department of Genetics
Brigham and Women's
Harvard Medical School
Boston University
24 Cummington Street LSE B01
Boston, MA 02215
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| Contact: |
Dr. Chip Celenza
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Noon - 1:00 PM
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HNRCA Spring Seminar Series with Dr. Xiao-Dong Cheng
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| Description: |
Join us for a seminar led by Dr. Xiao-Dong Cheng. The topic will be "Coordinated chromatin control: Structural and functional linkage of DNA and histone methylation".
Location:
Jean Mayer USDA HNRCA @ Tufts University, 711 Washington Street, Mezzanine Conference Room, Boston
The event is held in a government building, with security at the front door. In order to gain admittance you will need to bring a government ID to present at the door.
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| Contact: |
Christine O'Connell
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4:00 PM - 5:00 PM
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MGH CBRC Seminar Series
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| Description: |
Myles Brown, M.D.
Center for Functional Cancer Epigenetics
Dana-Farber Cancer Institute
"Epigenetic Programs of Hormone Dependent Cancers"
MGH EAST BUILDING 149
ISSELBACHER AUDITORIUM
7TH FLOOR
CHARLESTOWN MA
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| Contact: |
Bonnie Carroll
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| Tuesday, April 26, 2011
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12:30 PM - 1:30 PM
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The Amyloid State of Proteins
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| Description: |
Speaker: David Eisenberg, UCLA
Location: Harvard Med School, Warren Alpert Bldg, Room 341
Host: Drs. Collier and Hochschild
Coffee and snacks served at 12:15pm outside the room
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| Contact: |
Shannon Humphreys
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4:00 PM - 5:00 PM
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4:00 PM - 5:00 PM
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The Genetics of Cardiomyopathy In Man and Mouse
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| Description: |
Jonathan G. Seidman, Ph.D.
Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics
Department of Genetics, Harvard Medical School
"The Genetics of Cardiomyopathy In Man and Mouse"
Folkman Auditorium
John F. Enders Research Bldg., Children’s Hospital Boston
Cardiovascular Seminar Series
Department of Cardiology
This conference is supported by the Faye and Karen Sinclair Research Fund for Congenital Heart Disease
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| Contact: |
Michelle Merry
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| Wednesday, April 27, 2011
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Special Seminar with Caterina Strambio De Castillia
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| Description: |
The Department of Microbiology and Physiological Systems
The Program in Molecular Medicine, and
The program in Cell Dynamics
presents
Caterina Strambio De Castillia, PhD
Senior Research Scientist
Department of Microbiology and Molecular Medicine
University of Geneve, Switzerland
"A Cell Biologist Abroad: From A Single Cell View To Systems Virology
Wednesday, April 27
12:00pm-1:00pm
MaPS Seminar Room S5-310
Host: Allan Jacobson
A light lunch will be served immediately following the seminar in the MaPS Library, S5-106
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| Contact: |
Beverly Hobbs
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11:30 AM - 1:00 PM
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Bioinformatics Seminar Series: Modeling Intrinsically Disordered Proteins
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| Description: |
Speaker: Collin Stultz, MIT
Location: TOC Lab, Stata Center Room G575, MIT
A number of neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease involve the formation of protein aggregates. The primary constituent of these aggregates belongs to a unique class of heteropolymers called intrinsically disordered proteins (IDPs). While many proteins fold to a unique conformation that is determined by their amino acid sequence, IDPs do not adopt a single well-defined conformation in solution. Instead they populate a heterogeneous set of conformers under physiological conditions. Nevertheless, despite this intrinsic propensity for disorder, a number of these proteins can form ordered aggregates both in vitro and in vivo. As the formation of these aggregates may play an important role in disease pathogenesis, a detailed structural characterization of these proteins and their mechanism of aggregation is of critical importance. One problematic issue is that the characterization of intrinsically disordered proteins is quite challenging because accurate models of these systems require a description of both their thermally accessible conformers and the associated relative stabilities or weights. These structures and weights are typically chosen such that calculated ensemble averages agree with some set of prespecified experimental measurements; however, the large number of degrees of freedom in these systems typically leads to multiple conformational ensembles that are degenerate with respect to any given set of experimental observables. In this talk I will discuss a method for modeling these systems that is based on Bayesian statistics. A unique and powerful feature of the approach is that it provides a built-in error measure that allows one to assess the accuracy of the resulting ensemble. We apply the method to the intrinsically disordered proteins, tau protein and alpha synuclein, which have been implicated in the pathogenesis of Alzheimer’s disease and Parkinson’s disease, respectively. The models reveal specific patterns of long-range contacts that may play a role in the aggregation process.
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| Contact: |
Patrice Macaluso
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2:00 PM - 3:20 PM
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The Nature of Evidence to Establish the Clinical Utility of Pharmacoenomics Tests: A Regulatory Science Perspective
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| Description: |
Lawrence J. Lesko, Ph.D., Director, Office of Clinical Pharmacology and Biopharmaceutics, CDER, FDA Pharmacogenetics, Rockville, Maryland. Boston University School of Medicine, 72 East Concord Street, L-112, Boston, MA. Part of the Current Topics in Pharmacological Sciences Seminar Series sponsored by the Department of Pharmacology & Experimental Therapeutics. Free and open to the public. Refreshments served at 1:45 pm, R-Building 6th Floor.
www.bumc.bu.edu/busm-pm
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| Contact: |
Kristina Bigdeli
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2:15 PM - 3:15 PM
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MGH Cutaneous Biology Research Center Special Seminar
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| Description: |
Azeddine Atfi, Ph.D.
Harvard School of Dental Medicine
Department of Oral Medicine, Infection and Immunity
Mechanisms underlying inactivation of the TGF-β tumor suppressor network by the homeodomain proteinTGIF
MGH East, Building 149 Isselbacher Auditorium, 7th Floor, Charlestown, MA
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| Contact: |
Vivian Theodoracopoulos
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4:00 PM - 5:00 PM
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Neuroscience Seminar - Alice Ting
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| Description: |
Tufts University Neuroscience Seminar
Alice Ting, PhD, MIT
"Imaging protein function in living cells with enzyme-based reporters; application to the study of neurexin-neuroligin interactions in synapse remodeling"
Location:
Jaharis 508
150 Harrison Avenue
Boston, MA 02111
Handicap Accessible
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| Contact: |
Laila Lee
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5:00 PM - 6:00 PM
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| Thursday, April 28, 2011
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Noon - 1:00 PM
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Novel Resolvin and miR Circuits Activating Resolution of Acute Inflammation
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| Description: |
Speaker: Professor Charles N. Serhan, Center of Experimental Therapeutics and reperfusion Injury, Department of Anesthesia, Perioperative and Pain Medicine, BWH and Harvard Medical School
Location: The Forsyth Insitute, 245 First St., 17th Floor, Cambridge
Abstract: Mechanisms controlling the resolution of acute inflammation are essential to maintaining homeostasis, host defense and preventing persistent inflammation. The resolvins and protectins are novel pro-resolving mediators biosynthesized locally from polyunsaturated essential fatty acids and are the first mechanisms and molecules linking omega-3 nutrition status to the potent mediators of resolution and the return to homeostasis (CN Serhan, Am.
J. Path. 2010). This presentation will review recent evidence for the role of microRNAs (miRNAs) in self-limited acute inflammatory murine exudates and their regulation by omega-
3 derived resolvins. Using real-time PCR analysis and LC-MS-MS, we found that in resolving exudates resolvin (RvD1) is produced from DHA and that miR-21, miR-146b, miR-208a,
miR-203, miR-142, miR-302, and miR-219 are selectively regulated (P<0.05) in self-limited murine sterile peritonitis. The regulation of these miRs by resolvin D1 GPC receptors
identified in murine and human systems will be presented. RvD1 given in ng amounts/mouse reduced inflammation and neutrophil infiltration 25-50% into the peritoneum as well as
shortened the resolution interval (Ri) by ~4 h. In murine peritonitis at 12 h, RvD1 upregulates miR-21, miR-146b, and miR-219 and down-regulates miR-208a in vivo. With human macrophages overexpressing recombinant RvD1 receptors, which include both ALX/FPR2 and GPR32, we found that these miRNAs were regulated by RvD1 (p <0.05) as low as 10 nM in a receptor-dependent fashion. Hence, isolated human macrophages exposed to RvD1 recapitulate the in vivo circuit identified during the resolution of murine peritonitis. In addition, RvD1-miRNAs identified in these studies target cytokines and protein networks known to be involved in the immune system, e.g. miR-146b targeted NF-êB signaling, and miR-219 targeted 5-lipoxygenase that in turn reduces leukotriene production as monitored by LC-MS-MS-based lipid mediator lipidomics. Together these results indicate
that resolvins regulate specific miRNA target genes involved in resolution. Moreover, they establish a novel resolution circuit that involves omega-3 fatty acid-derived RvD1 and its
receptor-dependent regulation of specific miRNAs in vitro and in vivo. Moreover, they demonstrate the ability of pro-resolving GPCRs to regulate miR that impact inflammationresolution
via the essential PUFA.
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| Contact: |
Pam Quattrocchi
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1:00 PM - 6:00 PM
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Viruses: What we need to know to fight them
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| Description: |
Viruses: What we need to know to fight them
Thursday, April 28, 2011
1:00pm-6:00pm
Registration is free but required, and on a first-come, first-served basis
Speakers:
:: Steve Elledge, HHMI/Harvard Medical School
:: Yousuke Furuta, Toyama Chemical Company, Ltd.
:: Steve Harrison, HHMI/Harvard Medical School
:: Robert Lamb, HHMI/Northwestern University
:: Martin Nowak, Harvard University
:: Chaired by Hidde Ploegh, Whitehead Institute
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| Contact: |
Ceal Capistrano
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4:30 PM - 5:30 PM
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Vascular Biology Seminar: The Role of Computational Fluid Dynamics in Atherosclerosis Research
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| Description: |
Vartan Kurtcuoglu, Group Leader, Biofluidics, ETH Zurich, Switzerland, Visiting Scientist, Cardiovascular Medicine, BWH
Location: Folkman Auditorium, Enders Bldg., Children's Hospital Boston, 320 Longwood Ave.
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| Contact: |
David Lynn, 617-525-4351
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7:00 PM - 9:00 PM
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Network Science: From the Web to the Cell
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| Description: |
Highly interconnected networks with amazingly complex structure describe systems as diverse as the World Wide Web, our cells, social systems and the economy. In the past decade we learned that most of these networks are the result of self-organizing processes governed by simple but generic laws, resulting in architectural features that makes them much more similar to each other than one would have expected by chance. I will discuss the recurring patterns of our interconnected world and its implications to network robustness and spreading processes.
Albert-László Barabási is the former Emil T. Hofmann professor at the University of Notre Dame and current Distinguished Professor and Director of Northeastern University's Center for Complex Network Research (CCNR) and an associate member of the Center of Cancer Systems Biology (CCSB) at the Dana Farber Cancer Institute, Harvard University. He introduced the concept of scale-free networks in 1999 and proposed the Barabási–Albert model to explain their widespread emergence in natural, technological and social systems, Among the topics in network theory that Barabási has studied are growth and preferential attachment, the mechanisms probably responsible in part for the structure of the World Wide Web, usage patterns on cell phone networks and the cell.
Barabási is a Fellow of the American Physical Society, an external member of the Hungarian Academy of Sciences and a member of the Academia Europaea. In 2005 he was awarded the FEBS Anniversary Prize for Systems Biology and in 2006 the John von Neumann Medal by the John von Neumann Computer Society of Hungary.
He is the author of two well known books: "Linked: How Everything Is Connected to Everything Else and What it Means for Business, Science, and Everyday Life", 2002, and "Bursts: The Hidden Pattern Behind Everything We Do", 2010, and many articles including a long article "Statistical mechanics of complex networks", co-authored with Reka Albert, in Reviews of Modern Physics (Vol 74, no. 1, Jan 2002) that discusses much of the mathematical basis of his theories.
This joint meeting of the Boston Chapter of the IEEE Computer Society and GBC/ACM will be held in the Broad Institute Auditorium (MIT building NE-30). The Broad Institute is on Main St between Vassar and Ames streets.
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| Contact: |
Peter Mager
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| Friday, April 29, 2011
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8:00 AM - 9:00 AM
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Rheumatology Grand Rounds (BIDMC)
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| Description: |
Larry W. Moreland, M.D. Chief, Division of Rheumatology & Clinical Immunology at the University of Pittsburgh School of Medicine will speak on "Rheumatoid Arthritis: Therapeutic Options" Beth Israel Deaconess Medical Center, Rheumatology Grand Rounds, Friday, April 29th, 2011, 8:00 am, CLS-921 (Center for Life Sciences Bldg), 3 Blackfan Circle
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| Contact: |
Betty Chase
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1:30 PM - 2:45 PM
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1:30 PM - 2:45 PM
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Week of Sunday, April 24, 2011
