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Tuesday, April 19, 2011
8:00 AM - 1:00 PM
Proteomics 2011
Description: Proteomics symposium featuring Tony Pawson, SLRI, Toronto, Canada Ben Garcia, Princeton University, NJ Michal Sharon, Weizmann Institute, Israel Ruedi Aebersold, ETH Zurich, Switzerland Folkman Auditorium Children's Hospital Boston All are welcome, no registration required, event is free
Contact: Keith Solomon
12:30 PM - 1:30 PM
Bortetella Filamentous Hemagglutinin: A Modulator of Inflammation and a Model for Secretion-Dependent Protein Folding
Description: Speaker: Peggy A. Cotter, University of North Carolina - Chapel Hill
Location: Harvard Med School, Warren Alpert Bldg, Room 341
Host: Dr. John Mekalanos
Coffee and snacks served at 12:15pm outside the room
Contact: Shannon Humphreys
5:30 PM - 8:30 PM
Lessons in Sustainability
Description: Celebrate Earth Week and Enjoy a Free Lecture!

Harvard Medical School
The Armenise Amphitheater
200 Longwood Avenue - Boston, MA 02115

The Massachusetts AWIS chapter and the Harvard Office for Sustainability are pleased to co-host an evening lecture by Professor Nathan Phillips, Director of Boston University’s Center for Energy and Environmental Studies. The lecture will discuss how we can build resiliency into our infrastructure networks and Nathan will talk about how sustainable practices implemented by individuals in their homes and in the work place can make a lasting and dramatic impact.

The Lessons in Sustainability Seminar is a Free Lecture and Open to the Public!!!

If you plan to attend, we ask that you please register: http://www.acteva.com/booking.cfm?bevaid=217895

Agenda:
5:30-6:00pm: Welcome & Networking
6:00-7:00pm: Sustainability Seminar by Nathan Philips
7:00-8:30pm: Dinner & Networking
The event will be held in the Armenise Amphitheater.
Entrance to Armenise will be through the HMS Quadrangle.
For a detailed map, visit:
http://hms.harvard.edu/public/maps/lmamap.html Street parking and garages are available in the area. The MBTA’s Longwood Medical Area Station (Green Line E) & multiple bus stops are within walking distance.

To learn more about Mass-AWIS and other upcoming AWIS events, please visit: www.mass-awis.org. To learn more about Harvard’s Office for Sustainability, please visit:
http://green.harvard.edu/ofs/mission.

Contact: Anne-Elise Tobin
Wednesday, April 20, 2011
11:30 AM - 1:00 PM
Bioinformatics Seminar Series: Dimensionality reduction in the analysis of human genetics data
Description: Petros Drineas, RPI. MIT's CSAIL 32 Vassar Street Building 32 Room G575.

Dimensionality reduction algorithms (either deterministic or randomized) have been widely used for data analysis in numerous application domains, including the study of human genetics. For instance, linear dimensionality reduction techniques (such as Principal Components Analysis) have been extensively applied in population genetics. In this talk we will discuss such applications and their implications for human genetics, as well as the potential of applying non-linear or supervised dimensionality reduction techniques in this area.

Contact: Patrice Macaluso
2:00 PM - 3:20 PM
Ethanol Regulation of GABAA Receptor Trafficking: Mechanisms and Physiological Significance
Description: A. Leslie Morrow, Ph.D., John Andrews Distinguished Professor, Departments of Psychiatry and Pharmacology, Associate Director, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine. Boston University School of Medicine, 72 East Concord Street, R-115, Boston, MA. Part of the Current Topics in Pharmacological Sciences Seminar Series sponsored by the Department of Pharmacology & Experimental Therapeutics. Free and open to the public. Refreshments served at 1:45 pm, R-Building 6th Floor.

www.bumc.bu.edu/busm-pm
Contact: Kristina Bigdeli
6:00 PM - 7:30 PM
The Genetics of Autism Spectrum Disorders
Description: Professor Anthony Monaco, Pro-Vice-Chancellor (Planning and Resources) and Professor of Human Genetics at the University of Oxford
Please RSVP to lmavros@mit.edu if you'd like to attend.
Supported by the Simons Initiative on Autism and the Brain at MIT (web.mit.edu/autism)
Contact: Lee Mavros Rushton
Thursday, April 21, 2011
Noon - 1:00 PM
Mechanisms of biofilm formation, maturation, and dissemination in Staphylococcus epidermidis
Description: Speaker: Michael Otto, NIAID
Location: The Forsyth Institute, Seminar Room A, 245 First St., 17th Floor, Cambridge
Abstract: Biofilms are surface-attached agglomerations of microorganisms embedded in an extracellular matrix. Infections involving biofilms frequently develop on indwelling medical devices in hospitalized patients. Importantly, biofilm-associated infections are difficult to eradicate and represent a significant source for disseminating and recurring serious infections. In particular, the molecular determinants of biofilm dissemination are unknown. Staphylococcus epidermidis is the leading cause of biofilm-associated infections on indwelling medical devices. Biofilm formation in S. epidermidis is dependent on an exopolysaccharide called PIA with an additional function in immune evasion and a series of protein factors. Biofilm maturation and detachment are under control of quorum-sensing and mediated by specific secreted, surfactant-like peptides, the beta subclass of phenol-soluble modulins (PSMs). Importantly, these peptides promote the dissemination from colonized catheters in a mouse model of device-related infection, establishing in vivo significance of biofilm detachment mechanisms for the systemic spread of biofilm-associated infection.
Contact: Pam Quattrocchi
Friday, April 22, 2011
12:30 AM - 4:30 AM
decorative event image Cancer Genomics: Principles and Applications
Description: Nanocourse Announcement

TITLE: Cancer Genomics - Principles and Applications (https://nanosandquarters.hms.harvard.edu/node/159).

Speakers: Rameen Beroukhim, MD, PhD, Levi Garraway, MD, PhD, and John Quackenbush, PhD and Ben Ebert, MD

Dates & Location - DAY 1: Friday April 22, 12:30– 4:30pm in TMEC 250

Dates & Location - DAY 2: Thursday April 28, 2:30-5:30pm.

Course Description: Cancer genomics is a rapidly growing field that applies genome-scale technologies to develop comprehensive descriptions of cancer cells. A particular focus is the identification of genetic alterations that drive tumor growth and transcriptional, proteomic, and phenotypic correlates. An understanding of the biological impact of these alterations can potentially lead to the development cancer therapeutics. Currently many on-line tools are available that allow us to determine the impact of these alterations on tumor growth and development. Some of these resources include: Tumorscape (Broad Institute), COSMIC (Catalogue of Somatic Mutations in Cancer, Sanger), Cancer Gene Census (Sanger), Gene Expression Omnibus (NCBI), Oncomine (NCBI), and Gene Pattern (Broad). This nanocourse is designed to provide an introduction and an overview of the current on-line resources that are available on Cancer Genomics. The second session of this nanocourse will provide a hands-on approach to implementing these on-line resources in your research.

All are welcome.

Course Website: https://nanosandquarters.hms.harvard.edu/
Contact: Narveen Jandu
8:30 AM - 9:30 AM
Adapting to codon manipulations: Synonymous mutations in bacteria
Description: MSI weekly chalktalk! Please join us for coffee/tea/pastries at 8:30am in HUCE, 24 Oxford St, Room 310.
Speaker: Deepa Agashe (OEB)

http://www.msi.harvard.edu/events/fridays.html
Contact: Andrea Lenco
1:25 PM - 2:45 PM
Boston University School of Medicine Pathology and Laboratory Medicine Spring 2011 Seminar Series
Description: Guest Speaker: Beth McCormick, PhD; Professor of Molecular Genetics and Microbiology; University of Massachusetts Medical School. Talk Title: “Salmonella Typhimurium Interactions with the Intestinal Epithelium A Twist in the Tale of Bacterial Pathogenesis”

Boston University Medical Campus; 670 Albany Street (behind 700 Albany); Lobby Level #107/108
Contact: Debbie Kiley
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