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| Monday, October 3, 2011
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3:00 PM - 4:00 PM
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| Tuesday, October 4, 2011
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3:00 PM - 4:00 PM
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| Wednesday, October 5, 2011
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6:00 PM - 7:30 PM
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Common SNPs, rare CNVs. and the expression network between?
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| Description: |
Lauren A. Weiss, Ph.D., Staglin Family/IMHRO Assistant Professor, University of California, San Francisco
Please visit web.mit.edu/autism for further details, including talk abstract.
Please RSVP to lmavros@mit.edu
Supported by the Simons Initiative on Autism and the Brain at MIT (web.mit.edu/autism)
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| Contact: |
Lee Mavros Rushton
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| Thursday, October 6, 2011
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Noon - 1:25 PM
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Developmental endothelial locus-1 (Del-1) is required for periodontal tissue homeostasis and prevention of IL-17-mediated pathology
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| Description: |
Speaker: George Hajishengallis, DDS, PhD, University of Louisville School of Dentistry, Professor, Dept. of Microbiology and Immunology School of Medicine (joint appointment)
Location: The Forsyth Institute, Seminar Room A, 245 First Street, 17th Floor, Cambridge
Summary: The endothelial-secreted glycoprotein Del-1 (developmental endothelial locus-1) is a novel inhibitor of integrin-dependent neutrophil adhesion. In this seminar, evidence will be presented that Del-1 regulates local tissue-specific inflammation and controls chronic inflammatory disease. Upon aging, normal mice developed periodontitis accompanied by diminished Del-1 expression. Consistent with a homeostatic role for Del-1, Del-1-/- mice developed spontaneous periodontitis featuring excessive local neutrophil infiltration and IL-17 expression. Periodontitis was reversed in Del-1-/- mice with additional deficiencies in the LFA-1 integrin or the IL-17 receptor. Intriguingly, Del-1 and IL-17 were reciprocally cross-regulated and the diminished expression of Del-1 in old age was associated with elevated IL-17 expression. Importantly, however, age-associated periodontal inflammation and bone loss was suppressed by local administration of Del-1. In conclusion, Del-1 inhibits LFA-1-dependent neutrophil recruitment and IL-17-mediated pathology and may be a promising novel therapeutic for periodontitis and perhaps other inflammatory diseases.
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Pam Quattrocchi
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2:00 PM - 5:30 PM
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From Drug Delivery to Tissue Engineering
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| Description: |
Opening Remarks
Jeffrey S. Flier, MD, Dean of the Faculty of Medicine, Harvard University
Award Lectures-Bioengineering and its Impact on the Changing World of Cardiac Surgery
Alain F. Carpentier, MD, PhD, the head of the Department of Cardiovascular Surgery at the Hôpital Européen Georges Pompidou and winner of the 2011 Warren Alpert Foundation Prize for developing the world’s first artificial valve used in clinical practice.
Biomaterials and Biotechnology: From the Development of Controlled Drug Delivery Systems to the Foundation of Tissue Engineering
Robert Langer Jr., ScD, senior lecturer on surgery at HMS and the David H. Koch Institute Professor at MIT and winner of the 2011 Warren Alpert Foundation Prize for developing polymers to deliver drugs continuously at controlled rates over time and engineering blood vessels and vascularized skeletal muscle tissue.
Invited Lectures-Infection-Mimicking Polymers as a Cancer Vaccine
David J. Mooney, PhD, School of Applied Engineering and Wyss Institute for Biologically Inspired Engineering, Harvard University
Cancer Nanotechnology to Hepatic Tissue Engineering
Sangeeta Bhatia, MD, PhD, Health Sciences and Technology and Electrical Engineering and Computer Science, Massachusetts Institute of Technology
DNA Nanostructures as Building Blocks for Future Therapeutics
William Shih, PhD, Dana-Farber Cancer Institute, Harvard Medical School and Wyss Institute for Biologically Inspired Engineering, Harvard University
Location: Joseph B. Martin Conference Center, New Research Building, Harvard Medical School, 77 Avenue Louis Pasteur, Boston
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Caitlin Craig
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4:00 PM - 5:00 PM
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The Role of Extracellular Matrix Stiffening in Endothelial Cell Function
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| Description: |
Cynthia Reinhart-King, Cornell University, Biomedical Engineering
Room 203, Conference Center, Engineering Research Building (ERB), Boston University, 44 Cummington Street
HOST: Dr. Kathleen Morgan
Refreshments will be served
For more information on Dr. Reinhart-King go to:
www.cellmechanics.org
http://www.bme.cornell.edu/people/faculty/profile.cfm?id=3686
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| Contact: |
Danka Charland
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| Friday, October 7, 2011
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8:30 AM - 9:30 AM
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Week of Sunday, October 2, 2011
