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| Tuesday, March 6, 2012
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Noon - 1:00 PM
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12:30 PM - 1:30 PM
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| Wednesday, March 7, 2012
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Noon - 1:00 PM
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Homeostasis in cluster of epithelial cell rest of Malassez maintain by putative epithelial stem cells
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| Description: |
Masaki Honda, DDS., Ph.D., Associate Professor, Department of Anatomy, Nihon University School of Dentistry, Japan
Location: The Forsyth Institute, Seminar Rm. A, 245 First St., 17th Fl., Cambridge
Summary: The fragmented epithelial cells of the Hertwig's epithelial root sheath are retained in the periodontal ligament (PDL) where they persist in small clusters known as epithelial cell rest of Malassez (ERM). It is generally agreed that ERM is maintained as a quiescent and exclusively dental epithelial cluster in PDL, however, we speculate that homeostasis underlies the mechanism of maintaining the cluster. We also hypothesize that the fate of ERM clusters, diminishing or remaining, might be regulated via the presence or absence of epithelial stem cells in ERM clusters.
In fact, ERM clusters in the PDL of mouse first molars gradually increased in size with age until postnatal day 270. Immunocytochemistry and cell culturing to examine the cellular activity of ERM cells revealed KI67-positive cells and ERM cells that had migrated from PDL, expanded by culturing. Apoptosis was also detected in ERM clusters by TUNEL staining. Finally, we identified putative epithelial stem cells in the ERM clusters using two strategies: BrdU pulse-chase experiments. These results ssugested that the clusters of ERM are maintaining via frequent cellular turnover in the PDL throughout life.
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Pam Quattrocchi
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6:00 PM - 7:30 PM
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Linguistic and cognitive profiles in autism and the broad autism phenotype
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Molly Losh, Ph.D., Jane Steiner Hoffman and Michael Hoffman Assistant Professor, Northwestern University
Please RSVP to lmavros@mit.edu
Visit website for talk abstract: web.mit.edu/autism
The Simons Center for the Social Brain Colloquium Series
is a continuation of the Simons Initiative on Autism and the Brain’s Autism and Developmental Disorders Colloquium Series at MIT (web.mit.edu/autism).
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Lee Mavros Rushton
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| Thursday, March 8, 2012
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Noon - 1:00 PM
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A gene-to-molecule approach to discovering and characterizing small molecules from microbes
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Speaker: Michael Fischbach, PhD, University of California, San Francisco
Location: The Forsyth Institute, Seminar Room A, 245 First St., 17th Fl., Cambridge
Abstract: The discovery of natural products – small molecules from microbes often used as drugs – has been an ad hoc pursuit for almost a century. The rapidly growing database of microbial genome sequences offers new opportunities to leverage genomics and bioinformatics toward discovering natural products and characterizing their roles in mediating interspecies interactions. This lecture will describe three convergent, ongoing lines of research: our use of genomics and bioinformatics to identify biosynthetic genes and predict the structures of their small molecule products, our characterization of a new class of biosynthetic gene clusters that produce a set of heavily modified peptide antibiotics, and our efforts to identify and characterize small molecules produced by human-associated microbes.
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Pam Quattrocchi
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5:30 PM - 7:00 PM
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Microbial Facebook: probing bacterial social networks
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MSI Monthly Thursday Seminar. Please join us for a wine and cheese reception at 5:30, followed by the seminar at 6:00PM.
Speaker: Marvin Whiteley (University of Texas at Austin)
Location: HUCE (Harvard Center for the Environment) at 24 Oxford St, 3rd Floor, Room 310
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Andrea Lenco
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Week of Sunday, March 4, 2012
