|
|
| Monday, May 7, 2012
|
|
Noon - 1:00 PM
|
|
Tufts HNRCA Seminar Series ~ Stephen Hursting
|
| Description: |
This lecture given by Dr. Stephen Hursting of the University of Texas at Austin is titled: Energy Balance and Cancer Prevention: Mechanistic Insights from Transdisciplinary Studies.
Seminars will be held at 12 noon in the Auditorium of the HNRCA and will be followed by a student and post-doc luncheon on the 9th floor, 711 Washington St. Boston, MA 02111.
|
| Contact: |
John Heine
|
|
| Tuesday, May 8, 2012
|
|
12:30 PM - 1:30 PM
|
|
| Wednesday, May 9, 2012
|
|
12:30 AM - 1:30 AM
|
|
|
11:30 AM - 1:00 PM
|
|
Bioinformatics Seminar Series: Computational design of protein-based inhibitors
|
| Description: |
Julia Shifman, The Hebrew University of Jerusalem
TOC LAB, Stata Center 32-G575
Computational methods have been successfully applied to design of many monomeric proteins. Nevertheless, design of protein-protein interactions remains a more challenging and less explored task. Moderate success in this area is due to inability of the existing methods to reproduce favorable intermolecular interactions that govern binding of natural proteins. We developed improved computational methods for design of protein-protein complexes and tested them experimentally in three different systems. In the first example, we convert a promiscuous binder calmodulin into a very specific protein that recognizes a single target. In the second example, we enhance binding affinity of a complex between a synaptic enzyme acetylcholinesterase and its inhibitor fasciculin. In the third example, we computationally design a de novo binder to Ras, a molecular switch whose loss of function leads to cancer. Our experimental results are fed back into the design procedure, facilitating constant improvement of the computational methodology.
|
| Contact: |
Patrice Macaluso
|
|
|
Noon - 1:00 PM
|
|
| Thursday, May 10, 2012
|
|
4:00 PM - 5:00 PM
|
|
| Friday, May 11, 2012
|
|
12:30 PM - 1:30 PM
|
|
Radical approaches to antibacterials and drug resistance
|
| Description: |
Seminar Series - James J. Collins, Ph.D., William F. Warren Distinguished Professor University Professor and Professor of Biomedical Engineering Co-Director, Center for BioDynamics, Boston University; Wyss Institute for Biologically Inspired Engineering, Harvard University
Location: Latham Library, Harvard Medical School, 200 Longwood Ave
Hosted by: Wesley Wong
|
| Contact: |
Zac DiPasquale
|
|
 |
|
|
Week of Sunday, May 6, 2012
