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| Tuesday, April 17, 2012
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12:30 PM - 1:30 PM
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| Wednesday, April 18, 2012
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(All Day)
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MDx Next: Molecular Diagnostics Conference
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| Description: |
Practical conference sessions will tackle key questions and hot topics in molecular diagnostic and genetic testing, including:
As molecular markets get increasingly crowded, what are the best testing opportunities, how should they be priced, and do they make financial sense for your laboratory?
How can laboratories best build and optimize their molecular test menus?
With the wave of molecular diagnostics-based partnerships involving diagnostics companies and major pharmaceutical players, where do hospital labs fit in?
How are pharmacogenomics and personalized medicine affecting the interaction of clinical labs and physician practices?
What are the leading risks and challenges you should be aware of in the next two to three years in this market?
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| Contact: |
Stephanie Murg
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| Thursday, April 19, 2012
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(All Day)
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MDx Next: Molecular Diagnostics Conference
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| Description: |
Practical conference sessions will tackle key questions and hot topics in molecular diagnostic and genetic testing, including:
As molecular markets get increasingly crowded, what are the best testing opportunities, how should they be priced, and do they make financial sense for your laboratory?
How can laboratories best build and optimize their molecular test menus?
With the wave of molecular diagnostics-based partnerships involving diagnostics companies and major pharmaceutical players, where do hospital labs fit in?
How are pharmacogenomics and personalized medicine affecting the interaction of clinical labs and physician practices?
What are the leading risks and challenges you should be aware of in the next two to three years in this market?
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Stephanie Murg
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Noon - 1:00 PM
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What’s in a name? - Genetic and phenotypic heterogeneity in oral pathogens and commensals
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| Description: |
Speaker: Robert A. Burne, PhD, Department of Oral Biology, University of Florida College of Dentistry
Location: The Forsyth Institute, Seminar Room A, 245 First St., 17th Floor, Cambridge
Summary: The development of oral infectious diseases is accompanied by changes in the microbial composition and biochemical activities of oral biofilms. In the case of dental caries, it is known that the initiation and progression of disease is associated with an increase in theproportions of acid-tolerant species, many of which can grow and produce acids at pH values well below those that damage tooth mineral. High throughput technologies have been used effectively to quantify microbial diversity in healthy and carious sites, but clear associations of particular organisms with health and disease are not always apparent or consistent. Studies will be presented that address three major challenges in correlating oral microbiome composition with dental health. The first will detail evolutionary and functional genomic approaches to dissect the basis for phenotypic heterogeneity within the species Streptococcus mutans. The second explores the microbiological and molecular basis for the diminished capacity of oralbiofilms of caries-active subjects to moderate acidification through metabolism of salivary substrates. The third will describe the use of a novel microfluidics-based system to study, at the single cell level, the effects of microenvironments on intercellular communication systems of S. mutans. Collectively, these studies augment ongoing metagenomic approaches by disclosing how genetic heterogeneity and phenotypic plasticity impact the pathogenic potential of oral biofilms
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Pam Quattrocchi
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3:00 PM - 5:30 PM
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Understanding cancer and other complex traits using physical and genetic networks
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| Description: |
Trey Ideker, PhD
Department of Medicine, University of California, San Diego, USA, 92093-0688
Physical and genetic mapping data have become as important to Network Biology as they were to the Human Genome Project. Physical interaction maps are being constructed through systematic measurements of protein-protein, protein-DNA, and protein-small molecule interactions. Genetic interaction maps are being generated by large-scale screening of synthetic-lethals and epistasis, by multipoint gene association studies, and by mapping the effects of natural and prescribed genetic variations on gene expression. We are working on ways of integrating physical and genetic interaction maps to assemble models of molecular regulatory and signaling networks. We show how these network models can be used to address a variety of biomedical endpoints, including network-based patient stratification, drug target discovery, and genome-wide association studies. These efforts face several challenges, including: increasing the coverage of each type of network; establishing methods to assemble individual interaction measurements into contiguous pathway models; and annotating these pathways with detailed functional information.
Broad Institute
7 Cambridge Center Auditorium (NE30-1154)
3:00 PM - Tea and Reception (Main Lobby)
4:00 PM - Lecture (Auditorium)
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Linda Hill-White
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Week of Sunday, April 15, 2012
