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Tuesday, November 20, 2012
Noon - 1:00 PM
Immune based therapeutic approaches to Clostridium difficile infection
Description: Speaker: Saul Tzipori, DVM, PhD, DSc, FRCVS, Distinguished Professor of Microbiology/Infectious Diseases Agnes Varis University Chair in Science and Society Director, Division of Infectious Diseases, Cummings School of Veterinary Medicine Tufts University
Location: The Forsyth Institute, Seminar room A, 245 First Street, 17th Floor, Cambridge
Summary: A dramatic increase in morbidity and mortality from Clostridium difficile infection (CDI) due to the recent emergence of virulent, antibiotic resistant strains, has led to a search for alternatives to antibiotics, including vaccines and immune-based therapy targeting the two key toxins, TcdA and TcdB. The presentation will discuss the efficacy of specific human monoclonal (HuMab) and alpaca polyclonal antibodies against each toxin separately, and in combination, in the gnotobiotic piglet model of CDI. The development and characterization of a new human microbiome model in the germfree pig will also be discussed.
Contact: Pam Quattrocchi
4:00 PM - 5:00 PM
Neuregulin/erbB Signaling and Cardiovascular Endothelium
Description: Cardiovascular Seminar Series
Department of Cardiology | Boston Children’s Hospital
Kerry Russell, M.D., Ph.D., Associate Professor of Medicine, Cardiovascular Medicine, Internal Medicine Hospital, Yale University
Folkman Auditorium, John F. Enders Research Bldg., Children's Hospital
This conference is supported by the Faye and Karen Sinclair Research Fund for Congenital Heart Disease
D e p a r t m e n t o f C a r d i o l o g y | B o s t o n C h i l d r e n ’ s H o s p i t a l
Contact: Michelle Merry
4:00 PM - 5:00 PM
Seminars in Oncology: "Defining Patterns and Mechanisms of Tissue Stem Cell Fate Choices and Wnt Signal Transduction"
Description: Guest Speaker: Allon M. Klein, PhD, Postdoctoral Fellow, Department of Systems Biology, Harvard Medical School
Location: Jimmy Fund Auditorium, Dana-Farber Cancer Institute, (35 Binney Street - Boston)
Hosted by: Ramesh Shivdasani, MD, PhD, 617-582-7646.
Contact: Claudia Steele
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