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| Wednesday, October 3, 2012
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5:30 PM - 7:00 PM
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MSI Graduate Consortium Reception and Information Session
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| Description: |
Location: Harvard University Center for the Environment (HUCE)- climate change exhibit area/seminar room, 24 Oxford St (Cambridge), 3rd Floor, Room 310
Host: Roberto Kolter
Description: MSI welcomes Harvard graduate students with an interest in any aspect of the microbial sciences to join this vibrant interdisciplinary community. The evening will be an opportunity to socialize with current and prospective members of the consortium and to learn more about the program.
RSVP: to Nora Millan Rivas at nemrivas@fas.harvard.edu
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| Contact: |
Nora Millan Rivas
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6:00 PM - 7:30 PM
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| Thursday, October 4, 2012
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7:00 AM - 5:30 PM
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The 1st Official Conference of ICBS2012
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| Description: |
Keynote lectures
• Stuart Schreiber, HHMI and Broad Institute of Harvard and MIT, US
• Lewis Cantley, Harvard Medical School, US
• Paul Workman, The Institute of Cancer Research, UK
For more information visit www.chemical-biology.org/ICBS2012
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| Contact: |
Lauren Bautista
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9:00 AM - 5:00 PM
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Noon - 1:00 PM
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From Transcription to Morphogenesis: Foxc1, Msx2 and the Patterned Growth of the Mammalian Skull
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| Description: |
Speaker: Robert Maxson, PhD, Professor of Biochemistry & Molecular Biology, Keck School of Medicine USC
Location: The Forsyth Institute, Seminar Rooms A & B, 245 First Street, 17th Floor, Cambridge
Summary: My talk will have two parts. In the first, I will focus on the morphogenetic mechanisms by which the bones of the skull vault grow. I will discuss an interaction between the transcription factors, Foxc1 and Msx2, that has a crucial part in the initial specification of osteoprogenitor cells that give rise to the frontal and parietal bones. We have found that the forkhead transcription factor, Foxc1 regulates the influence of Bmps on the expression of Msx2 and the specification of osteogenic precursor cells in the developing skull vault. Foxc1 acts directly on an Msx2 upstream enhancer to restrict Msx2 expression to an osteogenic zone in the developing frontal bone: In Foxc1 mutants, Msx2 expression, and the osteogenic domain, expand resulting in the premature differentiation of osteogenic precursor cells and the consequent failure of skull vault growth. In the second part of the talk, I will discuss the pathophysiology of craniosynostosis, the fusion of calvarial bones at the sutures. I will describe a regulatory network in which Twist1 and its basic helix loop helix partner, Tcf12, are at the top of a hierarchy, controlling two independent pathways, ephrin-Eph and Jagged1/Notch. Ephrin-Eph functions in the guidance of osteogenic cells to their destinations in the developing frontal and parietal bones. A failure of this process results in mis-migration of osteogenic precursor cells into the coronal suture. Jagged1/Notch functions in the initial specification of sutural cells and in the boundary between the osteogenic and non-osteogenic compartments in the coronal suture. Together these two mechanisms underlie craniosynostosis in Twist1 mutant mice and, we propose, in humans with Twist1 mutations.
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| Contact: |
Pam Quattrocchi
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12:15 PM
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| Friday, October 5, 2012
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(All Day)
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Week of Sunday, September 30, 2012
