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| Tuesday, May 24, 2011
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12:30 PM - 1:30 PM
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| Thursday, May 26, 2011
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Noon - 1:00 PM
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State of the Union between metabolism and the immune system in type 2 diabetes
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| Description: |
Speaker: Barbara Nikolajczyk, Boston University School of Medicine
Location: The Forsyth Institute, Seminar Room A, 245 First St., 17th Floor, Cambridge
Summary: The relatively recent appreciation of obesity, insulin resistance and type 2 diabetes (T2D) as chronic inflammatory diseases has stimulated interest in understanding the role immune cells play in metabolic imbalance. Myeloid cells regulate inflammation through cytokine production and the adipose tissue remodeling that accompanies hyper-nutrition, thus are critical players in metabolic homeostasis. More recent studies have indicated a role for T cells in obesity-associated inflammation and insulin resistance in model organisms, with parallel with our work indicating that pro-inflammatory changes in T cells also associate with human T2D. Parallel pro-inflammatory changes in the B cell compartment of T2D patients have also been identified. Taken together, these studies indicate that, in addition to accepted pro-inflammatory roles of myeloid cells in T2D, pro-inflammatory skewing of both major lymphocyte subsets plays an important role in T2D disease pathogenesis. We propose a model for inflammation in T2D that functionally links lymphocyte, myeloid and adipocyte contributions and, importantly, proposes that immunomodulatory drugs may have a place in the Endocrinologist’s limited arsenal.
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Pam Quattrocchi
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4:00 PM - 5:00 PM
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Regulation of Epithelial Polarity by the PAR Complex
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Tufts University Program in Cell, Molecular and Developmental Biology Seminar Series
Guest Speaker: Tony Harris, PhD, Department of Cell and Systems Biology, University of Toronto
Location: Tufts University Behrakis Auditorium, The Jaharis Family Center for Biomedical and Nutritional Sciences, 150 Harrison Avenue, Boston
There will be a wine and cheese reception immediately following the seminar in the 5th floor library at 136 Harrison Avenue, Boston
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Sharon Titus
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4:30 PM - 5:30 PM
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Week of Sunday, May 22, 2011
