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| Monday, March 11, 2013
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Noon - 1:00 PM
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| Tuesday, March 12, 2013
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12:30 PM - 1:30 PM
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| Wednesday, March 13, 2013
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11:30 AM - 1:00 PM
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Bioinformatics Seminar Series:MONGOOSE - a new approach to metabolic network analysis
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| Description: |
Leonid Chindelevitch, Harvard School of Public Health
TOC Lab Stata Center Building 32-Room G575
Constraint-based metabolic models are currently the only methodology that allows metabolic network analysis on a genome-scale. Curiously, the results of flux balance analysis analysis may vary with the software being run. We introduce MONGOOSE (MetabOlic Network GrOwth Optimization Solved Exactly), an algorithmic pipeline for analyzing the structure of constraint-based metabolic models in exact rational arithmetic. When applying the pipeline to 98 existing genome-scale metabolic network models we find that the biomass reaction is surprisingly blocked in nearly half of them. We propose a new principled approach for unblocking these reactions and extend it to other important problems: identifying essential and synthetic lethal reactions and designing minimal media.
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| Contact: |
Patrice Macaluso
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Noon - 3:30 PM
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RNAi Screening: From Design to Data Analysis
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| Description: |
Tissue culture cells have provided a powerful system for studying many fundamental problems in signal transduction, cell differentiation and physiology. However, functional studies in cultured cells were hampered in the past by the lack of a powerful method for perturbing gene activities. A turning point came with the discovery of RNA interference and its rapid rise from small scale to genome-scale screening. Today, the most commonly used approaches are based on long dsRNA for Drosophila cells, and either synthetic siRNAs or vector-expressed short hairpin RNAs (shRNAs) for mammalian cells. Driven by genome-sequence data, RNAi is now widely used in high-throughput (HT) screens in both basic and applied biology. It is a powerful method for addressing many cell biological questions, and its amenability for use in modifier screens in addition to direct loss of function screening has made it particularly useful for the analysis of signal transductions pathways. RNAi has also become a method of choice for key steps in the development of therapeutic agents, from target discovery and validation to the analysis of the mechanisms of action of small molecules. This nanocourse will focus on both the technology and applications of RNAi screens.
Location: TMEC Building, Room 250, Harvard
For more information visit https://nanosandothercourses.hms.harvard.edu/node/226
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| Contact: |
Leah Brault
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| Thursday, March 14, 2013
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4:30 PM - 5:30 PM
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5:30 PM - 7:00 PM
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6:00 PM - 9:00 PM
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WEST: The Value Builder
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| Description: |
Come and Learn the 5-V approach to building your own Value and Confidence as an Upcoming Leader
Value – how to identify, articulate and develop strengths, and re-vision your résumé
Values – how to recognize your personal bottom line, set boundaries, resolve internal conflicts, and make trade-offs
Vision – create an inspiring personal vision and clear the obstacles to putting it into action
Visibility – make strategic choices about where, when and how to be visible, and create an outreach strategy
Voice – develop confidence and “executive presence”, through more effective communication up, down and laterally, within your organization and outside of it.
Women who gain clarity about and practice these five V's have an excellent basis for developing a strong personal brand and a strategic career path.
Is this for you?
You are at a critical point in your career – you want to be more effective in your current role and ready yourself for the next.
You are concerned about what might hinder you from getting to the next level: lack of organizational support, demands in your personal life, and perceptions that often lead to career stagnation or worse, and would like to feel empowered to do something about it.
You want to build awareness of your accomplishments and articulate the business value of your work in a more consistent, confident way, but without being pushy.
Further benefits include improvements in:
How to be more productive, and achieve more with less effort and struggle
How to be more influential, and effective in relationships with others
How to be more strategic, and less reactive in their approach to everything, from conversations to business or career planning
How to be more confident in navigating or leading change and negotiating the financial value of their work
Location:
The Broad Institute of MIT and Harvard
Monadnock Room
7 Cambridge Center
Cambridge, MA 02142
Cost:
Members: $40; Non-Members: $60
A light dinner will be served.
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Jaime Mayo
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Week of Sunday, March 10, 2013
