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| Tuesday, February 19, 2013
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12:30 PM - 1:30 PM
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| Thursday, February 21, 2013
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Noon - 1:00 PM
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Single Molecule Arrays (Simoa) for the ultrasensitive detection of proteins and nucleic acids
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| Description: |
Speaker: David C. Duffy, PhD, Vice President, Research, Quanterix Corporation
Location: The Forsyth Institute, Seminar Room A, 245 First Street, Cambridge
Summary:We will describe the single molecule array technology —or Simoa—that allows multiple proteins to be detected at concentrations 1000-fold lower than is possible with current diagnostic technology. The technology has single molecule resolution, and is based on capturing and labeling protein molecules on magnetic beads, and imaging those beads in arrays of thousands of femtoliter wells. The ability to detect proteins at subfemtomolar concentrations enables biomarkers that are discovered using proteomic and genomic strategies to be measured in bodily fluids, and used as clinical diagnostics. We will provide examples of biomarker detection in cancer, neurological disorders, and infectious diseases, highlighting the collaboration with the Forsyth to detect biomarkers from Mycobacterium tuberculosis. A fully automated Simoa instrument, capable of multiplexed biomarker detection will be described, as well as Simoa assays for DNA and RNA.
Educational/Learning Objectives
•The audience will be educated on the fundamentals of an innovative single molecule technology for detecting protein and nucleic acid biomarkers.
•They will hear how the translation of biomarkers from discovery to measurement in the clinic is a major technological challenge facing the development of diagnostics.
•They will hear how more sensitive measurements of proteins in bodily fluids can be applied in cancer, neurology, and infectious diseases.
•They will also be educated on instrumentation used to make single molecule measurements.
_1_ Continuing education credits provided by The Forsyth Institute.*
*The Forsyth Institute is an ADA CERP recognized provider . ADA CERP is a service of the American Dental Association to assist dental professionals in identifying quality providers of continuing dental education. ADA CERP does not approve or endorse individual courses or instructors, nor does it imply acceptance of credit hours by boards of dentistry. Concerns or complaints about a CE provider may be directed to the provider or to ADA CERP at www.ada.org/cerp. The Forsyth Institute designates _1_continuing education credits.
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| Contact: |
Pam Quattrocchi
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| Friday, February 22, 2013
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8:30 AM - 9:30 AM
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Week of Sunday, February 17, 2013
