|
|
| Tuesday, February 1, 2011
|
|
Noon - 1:00 PM
|
|
Image Guided Tumor Ablation: Shifting Paradigms in Cancer Care
|
| Description: |
Location: The Forsyth Insitute, Seminar Room A
245 First Street, 17th Floor
Cambridge
Speaker: Damian E. Dupuy, MD, FACR
Professor of Diagnostic Imaging
The Warren Alpert School of Medicine of Brown
University
Director of Tumor Ablation
Rhode Island Hospital
Summary: For decades conventional treatment of solid malignancies in the head and neck, lung, liver and kidney has relied upon surgery, chemotherapy and radiotherapy. Such therapies can be toxic, invasive and costly. As the median age of the population increases many patients who develop these tumors may be too frail or elderly to undergo the standard treatment. In addition health care costs continue to rise and many expensive therapies don’t provide significant improvements in quality or quantity of life. Image-guided tumor ablation is a less invasive alternative that can be used alone or in conjunction with standard therapies to locally control tumors. Cat scan, ultrasound or magnetic resonance imaging provides image-guidance to place needle-like applicators into the target tumors whereby thermal or chemical treatment can be applied to directly destroy cancers. Image-guided tumor ablation is by and large an outpatient “bandaid” procedure that can be performed in the young or old at a fraction of the cost of conventional treatments. Clinical applications and data for this new treatment will be shown and reviewed.
|
| Contact: |
Pam Quattrocchi
|
|
|
12:30 PM - 1:30 PM
|
|
|
4:00 PM - 5:00 PM
|
|
| Wednesday, February 2, 2011
|
|
9:30 AM - 10:30 AM
|
|
|
2:00 PM - 3:20 PM
|
|
|
6:00 PM - 7:30 PM
|
|
| Thursday, February 3, 2011
|
|
4:00 PM - 5:30 PM
|
|
Memory: Enduring traces of external and internal attention
|
| Description: |
2011 MIT Colloquium on Brain and Cognition
Speaker Marvin M. Chun, Ph.D.,Yale University
Place MIT, Singleton Auditorium, 46-3002
Cognition can be broadly distinguished into perceptual processes that are focused on external information from the environment, and reflective processes focused on internal information arising from active mental representations (e.g., memories, thoughts, images). Attention can be directed either to such external (perceptual) or internal (reflective) information (Chun, Golomb, & Turk-Browne, 2011), and the traces of such processing yield different types of memories. FMRI experiments will show how selective processes separately influence the encoding and the retrieval of competing visual memories. This perceptual/reflective framework integrates a broad range of findings.
http://bcs.mit.edu/newsevents/colloquia.html
|
| Contact: |
Kathleen Dickey
|
|
|
4:30 PM - 5:30 PM
|
|
| Friday, February 4, 2011
|
|
8:30 AM - 9:30 AM
|
|
| Monday, February 7, 2011
|
|
4:00 PM - 6:00 PM
|
|
Dissolving Boundaries: Extending the Reach of Medicine and Public Health.
|
| Description: |
Please join us on February 7, 2011 from 4:00-6:00 PM at the Countway Library for a panel discussion with three distinguished leaders in global health and medicine. The event is free and open to all.
Dissolving Boundaries: Extending the Reach of Medicine and Public Health.
The fields of medicine and public health continue to change, confronting issues of ever-greater magnitude, and framed by debates concerning the boundaries between organized medicine and public health, national and global health concerns, and personal and societal responsibilities. Successful efforts to engage such issues are critically dependent upon a historical understanding of their evolution. The event will feature lecture and discussion from:
• Allan Brandt, Ph.D., Dean, Graduate School of Arts and Sciences; Professor of the History of Science; Amalie Moses Kass Professor of the History of Medicine.
• Julio Frenk, M.D., Ph.D., Dean of the Faculty, Harvard School of Public Health; T & G Angelopoulos Professor of Public Health and International Development, Harvard School of Public Health and Harvard Kennedy School
• Jeffrey S. Flier, M.D., Dean of the Faculty, Harvard Medical School; Caroline Shields Walker Professor of Medicine
An accompanying exhibit, curated by Center staff, will draw from the archival collections of key leaders in American public health from the twentieth century, including Leona Baumgartner, Allan Macy Butler, Philip Drinker, Alice Hamilton, D. Mark Hegsted, Howard Hiatt, Jean Mayer, David Rutstein, Richard Pearson Strong, and James Whittenberger.
RSVP to ContactCHoM@hms.harvard.edu
|
| Contact: |
Michael Dello Iacono
|
|
| Tuesday, February 8, 2011
|
|
12:30 PM - 1:30 PM
|
|
|
1:00 PM - 4:30 PM
|
|
RNAi Screening: From Design to Data Analysis
|
| Description: |
Course Lecturers: Steve Elledge, Ph.D., Stephanie Mohr, Ph.D.,
Norbert Perrimon, Ph.D., and Caroline Shamu, Ph.D.
Tissue culture cells have provided a powerful system for studying many fundamental problems in signal transduction, cell differentiation and physiology. However, functional studies in cultured cells were hampered in the past by the lack of a powerful method for perturbing gene activities. A turning point came with the discovery of RNA interference and its rapid rise from small scale to genome-scale screening. Today, the most commonly used approaches are based on long dsRNA for Drosophila cells, and either synthetic siRNAs or vector-expressed short hairpin RNAs (shRNAs) for mammalian cells. Driven by genome-sequence data, RNAi is now widely used in high-throughput (HT) screens in both basic and applied biology. It is a powerful method for addressing many cell biological questions, and its amenability for use in modifier screens in addition to direct loss of function screening has made it particularly useful for the analysis of signal transductions pathways. RNAi has also become a method of choice for key steps in the development of therapeutic agents, from target discovery and validation to the analysis of the mechanisms of action of small molecules. This nanocourse will focus on both the technology and applications of RNAi screens.
|
| Contact: |
Leah Brault
|
|
|
4:00 PM - 5:00 PM
|
|
|
4:00 PM - 5:00 PM
|
|
| Wednesday, February 9, 2011
|
|
11:30 AM - 1:00 PM
|
|
Bioinformatics Seminar Series: Discriminating coding and non-coding RNAs using comparative sequence analysis
|
| Description: |
MIT Stata Center TOC Lab 32-G575
In my talk, I will first briefly review challenges and the current
state-of-the-art for genome-wide annotation of non-coding RNAs. To accurately locate non-coding RNAs in a genome it turned out to be critical to know what parts are actually coding. Although there are many sophisticated protein gene finders and very good annotations exist for most model organisms, there are also ambiguous and non-standard situations in which these programs fail.
We have therefore developed a new algorithm called "RNAcode", a
program to detect coding regions in multiple sequence alignments that is optimized for emerging applications not covered by current protein gene finding software. Our algorithm combines evolutionary information from nucleotide substitution and gap patterns in a unified framework and also deals with real-life issues such as alignment and sequencing errors. It uses an explicit statistical model with no machine learning component and can therefore be applied "out of the box", without any training, to data from all domains of life.
I will demonstrate how RNAcode was used in combination with mass spectrometry experiments to predict and confirm seven novel short peptides in E. coli that have evaded annotation so far. As another example of a typical application, I will show how RNAcode can be used together with the structural RNA gene finder RNAz to study ambiguous cases of dual function genes that function on both the RNA and protein level.
|
| Contact: |
Patrice Macaluso
|
|
|
2:00 PM - 3:20 PM
|
|
Resolution Pharmacology
|
| Description: |
Thomas Van Dyke, DDS, Ph.D., Vice President for Clinical and Translational Research and Chair of Periodontology, Forsyth Institute, Cambridge, MA. Boston University School of Medicine, 72 East Concord St, Room L-112. Free and open to the public. Part of the Current Topics in Pharmacological Sciences Seminar Series sponsored by the Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine. Refreshments at 1:45 pm, BUSM, R-Building 6th Floor.
www.bumc.bu.edu/busm-pm
|
| Contact: |
Kristina Bigdeli
|
|
| Thursday, February 10, 2011
|
|
Noon - 2:00 PM
|
|
Obesity and its association with diabetes and periodontal disease
|
| Description: |
Location: The Forsyth Institute, Seminar Room A
245 First St., 17th Floor
Cambridge
Speaker: Edward J. Shillitoe, PhD
Department of Microbiology & Immunology
State University of New York College of Medicine
Summary: Obesity has developed into an epidemic in the western world, along with associated conditions such as type 2 diabetes, cardiovascular disease and periodontal disease. The cause of these conditions is poorly understood, but they can be reproduced in animal models simply by changing the balance of the normal flora. In humans, obesity and diabetes are treated most effectively by stomach bypass surgery, which alters both the immune response and the composition of the bacterial flora. This presentation will therefore outline the evidence that obesity and its associated conditions are an infectious epidemic, and will suggest how research might lead to improved management and prevention.
|
| Contact: |
Pam Quattrocchi
|
|
|
3:00 PM - 4:00 PM
|
|
|
4:00 PM - 5:30 PM
|
|
Bidwell Memorial Lecture: Amyotrophic Lateral Sclerosis (Lou Gehrig's disease): Lessons from Genetics
|
| Description: |
Speaker Robert H. Brown, Jr., D.Phil., M.D., Professor and Chair, Department of Neurology, University of Massachusetts Medical School, Worcester, MA
Place Singleton Auditorium, 46-3002
Amyotrophic lateral sclerosis (ALS) is an adult-onset degenerative disorder of motor neurons, typically leading to paralysis and death in five years or less. About 10% of cases are inherited, usually as dominant traits (familial ALS or FALS). Over the last two decades, several FALS genes have been identified, including SOD1, TDP43 and FUS/TLS. Numerous investigations support the view that the mutant proteins are unstable and readily provoked to misfold, thereby acquiring toxic properties. Transgenic expression of mutant SOD1 protein in mice and cells generates animal and cell-based models of FALS, which have assisted in elucidating molecular events and targets for therapy. More recent data suggest that post-translational modifications of non-mutant SOD1 confer toxic attributes on the protein in sporadic ALS, mimicking the influence of the SOD1 mutations in FALS. These investigations have identified broad themes in the biology of motor neuron disease as well as approaches to therapy; these concepts are likely to be relevant to other neurodegenerative disorders.
http://bcs.mit.edu/newsevents/colloquia.html
References (Bidwell 2011)
1. Rosen DR, Siddique T, Patterson D, Figelwicz DA, Sapp P, Hentati A, Donaldson D, Goto J, O'Regan, Den H, Rahamani Z, Krisus A, Berger R, Tanzi RE, Haperin JJ, Herzfeldt B, Van denBergh R, Hung W, Bird T, Deng G, Mulder DW, Smyth C, Nigel G, Soriano E, Pericak-Vance MA, Haines J, Rouleau GA, Gusella JS, Horvitz RH, Brown RH Jr. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362:59-62, 1993.
2. Kwiatkowski TJ, Bosco DA, LeClerc AL, Tamrazian E,VandenBerg CR, Russ C, Davis A, Gilchrist J, Kasarskis EJ, Munsat T, Valdmanis P, Rouleau GA, Hosler BA, Cortelli P, de Jong PJ, Yoshinaga Y, Haines JL, Pericak-Vance MA, Yan J, Ticozza N, Siddique T, McKenna-Yasek D, Sapp, PC, Horvitz HR, Landers JE, Brown RH, Jr. Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science 323(5918):1205-8, 2009.
3. Bosco DA, Morfini G, Karabacak NM , Song Y, Gros-Louis F, Pasinelli P, Goolsby H, Fontaine BA, Lemay N, McKenna-Yasek D, Frosch MP, Agar JN, Julien J-P, Brady ST, Brown RH, Jr. Wild-type and mutant superoxide dismutase share conformational alterations and trigger a common pathogenic mechanism in amyotrophic lateral sclerosis, Nature Neuroscience, Nov;13(11):1396-403, 2010.
|
| Contact: |
Kathleen Dickey
|
|
|
4:00 PM - 5:30 PM
|
|
Progress in understanding the mechanism of short-term and long-term memory
|
| Description: |
2011 MIT Colloquium on Brain and Cognition
Speaker John Lisman
Professor of Biology
Brandeis University
Time 4pm, Departmental Tea immediately following.
Date Thursday, 10 February 2011
Place Singleton Auditorium, 46-3002
Host Michael Fee
Abstract:
I will describe recent progress in understanding two forms of memory. Short-term memory can be stored by the persistent firing of neurons. Multiple items can be held in short-term memory and our recent work on the entorhinal cortex suggests that this involves theta and gamma frequency oscillations. This cortical region has two modes, a predictive (recall) mode and a retrospective (short-term memory) mode. These modes alternate in seconds. Our analysis of grid cell firing during the retrospective mode shows that short-term memories about different recently visited positions are active in different gamma cycles of a theta cycle. A theta-gamma code may thus be fundamental mechanism by which cortex and hippocampus represent multi-item messages. In the second part of my talk I will describe tests of the hypothesis that synaptic strength is stored by the complex of CaMKII with NR2B. Using 2-photon FRET, we found that LTP induction produces a synapse-specific increase in the complex. We then showed that the CN class of CaMKII inhibitors dissociates the CaMKII/NMDAR complex and thereby reverses LTP. This complex can thus serve as a molecular storage site for long-term memory.
|
| Contact: |
Vivi Hinh
|
|
|
4:30 PM - 5:30 PM
|
|
|
6:00 PM - 7:00 PM
|
|
|
6:00 PM - 9:00 PM
|
|
Alternative Careers for Scientists & Engineers
|
| Description: |
If you are exploring your options, leaving your job, or want to learn more about career choices, please join us. You will meet an extensive panel of "One-Night Mentors" who have experience breaking into and thriving in careers outside of academia. The Mentors will give short presentations, and then will be available for "speed networking" at separate tables where you can learn more about their careers and the paths that led them there. Topics include:
Business Development
Science Writing
Medical Liaison
Bioprocess Technology
IP Law
Technology Transfer
Operations & Services
And much, much more! Come to learn, expand your reach and broaden your perspective. Everyone is welcome to attend, light dinner and refreshments are included.
http://www.westorg.org/mc/page.do?sitePageId=122827
|
| Contact: |
Susan Silberman
|
|
| Friday, February 11, 2011
|
|
Noon - 1:30 PM
|
|
Neural networks underlying top-down enhancement and suppression of visual processing.
|
| Description: |
Adam Gazzaley, M.D., Ph.D.
Associate Professor of Neurology, Physiology and Psychiatry
Director, Neuroscience Imaging Center
University of California, San Francisco
Date: February 11th, 2011
Time: 12 PM
Location: Bldg. 46, Rm. 3002
Abstract:
Top-down modulation is a bi-directional process that underlies our ability to focus our attention on task-relevant stimuli and ignore irrelevant distractions by differentially enhancing or suppressing neural activity in sensory cortical regions. I will first present evidence using fMRI and EEG in younger and older adults that demonstrates that enhancement and suppression are dissociable processes. It is widely believed that this top-down modulation is not an intrinsic property of visual cortices, but is achieved via functional communication between sensory brain regions and a distributed network of frontal and parietal regions. I will next present fMRI data that reveals visual cortical areas that selectively process relevant information are functionally connected with a frontal-parietal network, while those processing irrelevant information are simultaneously coupled with the 'default-network'. This provides the first evidence that sensory cortical regions are differentially and dynamically coupled with distinct networks based on task goals. Lastly, using a multi-modal approach that couples fMRI, rTMS and EEG, I will present evidence for a direct role of the inferior frontal junction (IJF) in top-down enhancement and suppression, and its influence on subsequent working memory. All of the data presented will explore the role of top-down control networks in mediating the interaction between attention and memory systems.
|
| Contact: |
Vivi Hinh
|
|
|
1:30 PM - 2:45 PM
|
|
| Tuesday, February 15, 2011
|
|
12:30 PM - 1:30 PM
|
|
|
4:00 PM - 5:00 PM
|
|
| Wednesday, February 16, 2011
|
|
11:30 AM - 1:00 PM
|
|
Bioinformatics Seminar Series:The evolution of eusociality
|
| Description: |
Speaker: Corina Tarnita Stata Center 32-G575.
Eusociality, in which some individuals reduce their lifetime reproductive potential to raise the offspring of others, underlies the most advanced forms of social organization and the ecologically dominant role of social insects. For the past four decades, kin selection theory, based on the concept of inclusive fitness, has been the major theoretical attempt to explain the evolution of eusociality. In this talk I propose that standard natural selection theory in the context of precise models of population structure represents a simpler and superior approach, allows the evaluation of multiple competing hypotheses, and provides an exact framework for interpreting empirical observations.
http://www-math.mit.edu/compbiosem
|
| Contact: |
Patrice Macaluso
|
|
|
2:00 PM - 3:20 PM
|
|
Gamma-Secretase as a Target for Alzheimer Disease Therapy: Small Molecule Development
|
| Description: |
Corinne E. Augelli-Szafran, Ph.D., Director, Laboratory for Experimental Alzheimer Drugs (LEAD), Center for Neurologic Diseases, Brigham and Women's Hospital and Instructor in Neurology Harvard Medical School. Boston University School of Medicine, 72 East Concord Street, L-112, Boston, MA. Part of the Current Topics in Pharmacological Sciences Seminar Series sponsored by the Department of Pharmacology & Experimental Therapeutics. Free and open to the public. Refreshments served at 1:45 pm, R-Building 6th Floor.
www.bumc.bu.edu/busm-pm
|
| Contact: |
Kristina Bigdeli
|
|
|
6:00 PM - 7:30 PM
|
|
|
6:00 PM - 8:30 PM
|
|
Plants in New England (PINE)
|
| Description: |
Plants in New England
Note date change!
When: Wednesday February 16, 2011 at 6 pm
Where: Worcester Polytechnic Institute
Room GP1002
Gateway Park
60 Prescott St.
Worcester 01605
http://www.gatewayparkworcester.com/directions.html
(free parking is available right next door)
Speakers:
Horim Lee (Sheen Lab, MGH)
"Stem cell triggered immunity in the shoot apical meristem"
Ming Li (Bezanilla Lab, UMass, Amherst)
"PI(3,5)P2 is critical for tip-growth in moss "
Om Parkash (UMass, Amherst)
Title TBA
Talks will begin a bit after 6 pm lasting about 35-40 minutes each with a 5 minute break in between. Pizza and beverages will be available beginning at 5:45 pm.
Thanks to WPI's Department of Biology & Biotechnology and Department of Chemistry & Biochemistry for funding tonight’s meeting!
The next PINE will be Apr 6, 2011 (location TBA)
Please forward this email to any new students/post-docs/PIs who might be interested in attending.
|
| Contact: |
chip celenza
|
|
| Thursday, February 17, 2011
|
|
Noon - 1:00 PM
|
|
|
4:00 PM - 5:00 PM
|
|
Role of Small Peptides in Regulating Transcriptional Programs During Drosophila Development
|
| Description: |
Tufts University Program in Cell, Molecular and Developmental Biology Seminar Series
Guest Speaker: Francois Payre, PhD, Research Director, Universite de Toulouse, Toulouse, France
Location: Tufts University Sackler School of Graduate Biomedical Sciences. Sackler Auditorium, 145 Harrison Avenue, Boston, MA 02111
There will be a wine and cheese reception immediately following the seminar in the Anatomy Department 5th floor library at 136 Harrison Avenue
|
| Contact: |
Sharon Titus
|
|
|
4:30 PM - 5:30 PM
|
|
Vascular Biology Seminar: Krystyn J. Van Vliet, PhD
|
| Description: |
Krystyn J. Van Vliet, PhD
Paul M. Cook Associate Professor
Department of Materials Science & Engineering
Department of Biological Engineering
Massachusetts Institute of Technology
“Chemomechanics of Cell-matrix Interactions: Pulling Together Molecular Mechanisms"
Folkman Auditorium, Enders Bldg.
Children's Hospital Boston, 320 Longwood Ave.
|
| Contact: |
David Lynn, 617-525-4351
|
|
|
5:30 PM - 9:00 PM
|
|
WEST “Job Interviews: The Art & Strategy of Success" Workshop
|
| Description: |
Interviewing is a vital skill for succeeding in the world of science and technology. If 10 or 100 people are interviewing for the position you want, what puts you over the top and out in front? This lively, interactive workshop will focus on improving your ability to ask for informational interviews and make them productive. It will take the mystery out of key aspects of job interviewing, and teach you concrete skills for reaching out to others. Join us to learn:
How to grow your network strategically
Make the most of your informational interviews
Set achievable interviewing goals
Learn strategies for successful job interviews
This workshop is open to the public, everyone is welcome to attend! Light dinner & refreshments are included.
http://www.westorg.org/mc/page.do?sitePageId=122884
|
| Contact: |
Susan Silberman
|
|
| Friday, February 18, 2011
|
|
8:30 AM - 9:30 AM
|
|
Trying to ask quantitative questions about microbial evolution
|
| Description: |
Speaker: Michael Desai, FAS-OEB
Location: Harvard University Center for the Environment (HUCE), 24 Oxford St, 3rd Floor, Room 310
Notes: MSI Weekly Chalktalk! Please join us for coffee/tea/pastries at 8:30 AM, followed by the chalktalk at 8:45.
http://www.msi.harvard.edu/fridays.html
|
| Contact: |
Andrea Lenco
|
|
|
1:30 PM - 2:45 PM
|
|
| Tuesday, February 22, 2011
|
|
4:00 PM - 5:00 PM
|
|
|
6:00 PM - 9:30 PM
|
|
Mass-AWIS Communication Style Workshop
|
| Description: |
Announcing the 2011 Communication Style Workshop
Please join the Massachusetts AWIS chapter for a Communication Style Workshop hosted by Sarah Cardozo Duncan. Sarah is a Boston-based career strategist with over twenty years of recruitment and career development experience and she will be working with AWIS members to develop and refine their communication skills.
Communication Style Workshop
Tuesday, February 22, 2011
6:00-9:30pm
Lando & Anastasi
One Main Street, Eleventh Floor, Cambridge, MA 02142
The Communication Workshop is only open to 40 AWIS members. If you would like to attend the event and are not yet an AWIS member, please visit www.awis.org to sign up and be sure to select the Massachusetts Chapter.
Registration starts Monday, January 17th, 2011!!!
http://www.acteva.com/booking.cfm?bevaid=214332
$40 – AWIS Members
Street parking and garages are available in the area. The MBTA’s Kendall/MIT Station (Red Line) & multiple bus stops are within walking distance.
For information email: info@mass-awis.org
|
| Contact: |
Mass-AWIS
|
|
| Wednesday, February 23, 2011
|
|
11:30 AM - 1:00 PM
|
|
Bioinformatics Seminar Series: Probabilistic Graphical Model for Protein Structure Prediction
|
| Description: |
Speaker: Jinbo Xu, Toyota Technological Institute at Chicago
CSAIL 32-G575 TOC Lab Stat Center
If we know the primary sequence of a protein, can we predict its three-dimensional structure by computational methods? This is one of the most important and difficult problems in computational molecular biology and has tremendous implications for protein functional study and drug discovery.
Existing computational methods for protein structure prediction can be broadly classified into two categories: template-based modeling (i.e., protein threading/homology modeling) and template-free modeling (i.e., ab initio folding). Template-based modeling predicts structure of a protein using experimental structures in the Protein Data Bank (PDB) as templates while template-free modeling predicts protein structure without depending on a template.
This talk will present new probabilistic graphical models for knowledge-based protein structure prediction. In particular, this talk will present a regression-tree-based Conditional Random Fields (CRF) method for template-based modeling and a Conditional Random Fields/Conditional Neural Fields (CRF/CNF) method for template-free modeling. Experimental results indicate that our template-based method performs extremely well, especially on hard template-based modeling targets and our template-free method is also very promising for mainly-alpha proteins.
|
| Contact: |
Patrice Macaluso
|
|
|
2:00 PM - 3:20 PM
|
|
Chemokines and Microglia in Alzheimer’s Disease: Beyond Recruitment
|
| Description: |
Joseph El Khoury, M.D., Assistant Professor of Medicine, Harvard Medical School, Assistant in Medicine, Infectious Disease Unit, and Principal Investigator, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital. Boston University School of Medicine, 72 East Concord Street, L-112, Boston, MA. Part of the Current Topics in Pharmacological Sciences Seminar Series sponsored by the Department of Pharmacology & Experimental Therapeutics. Free and open to the public. Refreshments served at 1:45 pm, R-Building 6th Floor.
www.bumc.bu.edu/busm-pm
|
| Contact: |
Kristina Bigdeli
|
|
|
2:00 PM - 5:00 PM
|
Quantitative Microscopy Nanocourse Part I - Image Acquistion, with Jennifer Waters
|
| Description: |
Harvard Medical School Nanocourse Announcement - Quantitative Microscopy, Part I and Part II
Quantitative Microscopy, Part I: Image Acquisition, with Jennifer Waters
Wednesday, February 23rd
2:00pm – 5:00pm
HMS, Goldenson Building Room 122
The accuracy and precision of quantitative light microscopy measurements depends on the quality of the acquired digital images. Obtaining digital images suitable for quantitation requires careful consideration of specimen preparation, the mode of microscopy, and the optics, filters, and detector.
In Part I of this two-part course, we will (1) learn how to judge image quality; (2) discuss how the various choices of equipment and imaging parameters affect image quality; and (3) learn how to best make the compromises necessary in live cell experiments to balance image quality and acquisition speed while minimizing photo-toxicity.
AND
Quantitative Microscopy, Part II: Image Analysis, with Khuloud Jaqaman
Friday, February 25th
2:00pm – 5:00pm
HMS, Armenise Building (D) Amphitheater
Live-cell images often consist of punctate features representing single fluorophores tagging single molecules, sub-resolution fluorophore clusters associated with small molecular assemblies or fluorophore blobs associated with vesicles or more extended organelles.
In Part 2 of this two-part course, we will discuss basic principles of computer vision as applied to live-cell images, with an emphasis on the detection and tracking of punctate image features due to their abundance in cell biological applications. Topics covered include: (1) detection/segmentation; (2) localization; (3) resolution; (4) particle tracking/trajectory construction; and (5) image analysis software benchmarking.
All are welcome to attend. No registration is required. See nanosandquarters.hms.harvard.edu for the complete nancourse schedule.
|
| Contact: |
Ondra Kielbasa
|
|
|
3:30 PM - 5:30 PM
|
An Afternoon with Augustus A. White III, M.D.: Part of the 150 Celebrations
|
| Description: |
Location: MIT, Ray and Maria Stata Center, Kirsch Auditorium, building 32-123
Augustus A. White, III, M.D., professor of Medical Education and Orthopedic Surgery at Harvard Medical School, will discuss his compelling story of race, health and the profound inequality in proving health care in America. Seeing Patients, Dr. White’s new book, recounts his extraordinary journey from the segregated South to elite private schools and universities to Vietnam to chief of a department at Harvard’s teaching hospital.
Based on research and interviews with leading physicians coupled with his personal experiences, Dr. White shows how unconscious stereotyping influences doctor-patient interactions, diagnosis, and treatment.
Seeing Patients provides insight from social psychology, neuroscience, and clinical practice to define the issues clearly and to outline an approach to mitigate the fundamental inequality in the delivery of health care in America.
|
| Contact: |
Kathleen Dickey
|
|
|
4:00 PM - 5:00 PM
|
|
Neuroscience Seminar - Sandra Pena de Ortiz
|
| Description: |
Tufts University Neuroscience Seminar
Sandra Pena de Ortiz, University of Puerto Rico
Title: "Biobehavioral and Biochemical Processes in the Brain - A Neurolipidomics Approach"
Location:
150 Harrison Avenue, Jaharis 508
Boston, MA
|
| Contact: |
Laila Lee
|
|
| Friday, February 25, 2011
|
|
8:30 AM - 9:30 AM
|
|
Lessons from bacteria-nematode mutualisms
|
| Description: |
Speaker: Jason Crawford, HMS-BCMP
Location: Harvard University Center for the Environment (HUCE), 24 Oxford St, 3rd Floor, Room 310
Notes: MSI Weekly Chalktalk! Please join us for coffee/tea/pastries at 8:30 AM, followed by the chalktalk at 8:45.
http://www.msi.harvard.edu/fridays.html
|
| Contact: |
Andrea Lenco
|
|
|
1:30 PM - 2:45 PM
|
|
|
2:00 PM - 3:00 PM
|
|
Adaptive coding of auditory space
|
| Description: |
Andrew King, Ph.D.
Wellcome Principal Research Fellow and Professor of Neurophysiology at
the University of Oxford, UK
Sloan Teaching Room, 3rd Floor
Massachusetts Eye & Ear Infirmary
243 Charles St., Boston, MA 02114
|
| Contact: |
Nora Zatezalo
|
|
|
2:00 PM - 5:00 PM
|
|
Quantitative Microscopy Nanocourse Part II - Image Analysis, with Khuloud Jaqaman
|
| Description: |
Harvard Medical School Nanocourse Announcement - Quantitative Microscopy, Part I and Part II
Quantitative Microscopy, Part I: Image Acquisition, with Jennifer Waters
Wednesday, February 23rd
2:00pm – 5:00pm
HMS, Goldenson Building Room 122
The accuracy and precision of quantitative light microscopy measurements depends on the quality of the acquired digital images. Obtaining digital images suitable for quantitation requires careful consideration of specimen preparation, the mode of microscopy, and the optics, filters, and detector.
In Part I of this two-part course, we will (1) learn how to judge image quality; (2) discuss how the various choices of equipment and imaging parameters affect image quality; and (3) learn how to best make the compromises necessary in live cell experiments to balance image quality and acquisition speed while minimizing photo-toxicity.
AND
Quantitative Microscopy, Part II: Image Analysis, with Khuloud Jaqaman
Friday, February 25th
2:00pm – 5:00pm
HMS, Armenise Building (D) Amphitheater
Live-cell images often consist of punctate features representing single fluorophores tagging single molecules, sub-resolution fluorophore clusters associated with small molecular assemblies or fluorophore blobs associated with vesicles or more extended organelles. In Part 2 of this two-part course, we will discuss basic principles of computer vision as applied to live-cell images, with an emphasis on the detection and tracking of punctate image features due to their abundance in cell biological applications. Topics covered include: (1) detection/segmentation; (2) localization; (3) resolution; (4) particle tracking/trajectory construction; and (5) image analysis software benchmarking.
All are welcome to attend. No registration is required. See nanosandquarters.hms.harvard.edu for the complete nancourse schedule.
|
| Contact: |
Ondra Kielbasa
|
|
 |
|
|
Month of February 2011
