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| Thursday, July 12, 2012
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Noon - 1:00 PM
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Engineered Bone Surfaces: A new approach for bone repair
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| Description: |
Speaker: S. Adam Hacking, Ph.D., Director, Laboratory for Musculoskeletal Research and Innovation Orthopaedics, MGH
Location: The Forsyth Institute, Seminar Rooms A & B, 245 First Street, 17th Floor, Cambridge
Summary: For over 20 years, the application of micro and nano-sized features to the surface of titanium implants has been recognized as a predictable means to enhance osseointegration. Worldwide, dental and orthopaedic devices with textured surfaces are implanted over 500,000 times annually. Given the extent and duration of clinical use, it is surprising that a biologic rationale for action has not been proposed. My group is interested in biomimetic cues that guide tissue repair. We considered regions and features associated with bone formation and determined that osteoclast resorption pits and the fracture surfaces were candidates for study. In this seminar, I will present data that suggests the osseous response to textured implant surfaces may in fact be part of a programmed response to the fracture surface of bone. By taking morphological cues from the fracture surface, we have modified the native ‘smooth’ surface of cortical and cancellous bone to include micro and nano-sized features. We have produced engineered bone surfaces that increase the extent of new bone formation in rat and rabbit animal models.
This presentation will provide a review of the fundamentals of surface topography measurement, recent advances in techniques to evaluate the osseous response to biomaterials and will provide data from in vivo and in vitro studies.
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| Contact: |
Pam Quattrocchi
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| Thursday, July 19, 2012
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(All Day)
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Cell Based Assays Americas
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| Description: |
July 19 and July 20, 2012
The Seaport Hotel
1 Seaport Lane, Boston, MA
(617) 385-4000
Speakers
1. Sashi Nadanaciva, Pfizer
2. Arijit Chakravarty, Millennium Pharmaceuticals
3. Douglas Auld, Novartis
4. Regis Doyonnas, Pfizer
5. Robert Graves, GE Healthcare
6.Tetsuro Wakatsuki, InvivoSciences
7. Peter Sartipy, Cellectis Stem Cells
8. Grant Cameron, TAP Biosystems
9. Grace Wong, Actokine Therapeutics (also chair)
10. Thorsten Gorba, StemCells, Inc
11. Jim Beltzer, Terumo BCT
12. Deborah Moshinsky, Cell Assay Innovations
13. Okechukwu Ukairo, Hepregen Corporation
14. Mehmet Fatih Yanik, MIT
15. Marcie Glicksman, Harvard
16. Shantanu Singh, Broad Institute of Harvard and MIT
Dr Grace, ActoKine will be a speaker & chair and she earns free passes for students, postdocs & scientists. To apply for a free pass, register at www.nobel-pauling.org
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Alex Pauling
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Month of July 2012
