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Monday, May 2, 2011
Noon - 1:00 PM
HNRCA Spring Seminar Series with Dr. Manel Esteller
Description: Join us for a seminar led by Dr. Manel Esteller. The topic will be "Human Cancer Epigenetics".
Location: Jean Mayer USDA HNRCA @ Tufts University, 711 Washington Street, Mezzanine Conference Room, Boston
The event is held in a government building, with security at the front door. In order to gain admittance you will need to bring a government ID to present at the door.
Contact: Christine O'Connell
Noon - 1:00 PM
biolomolecular Seminar Series
Description: " mi RNAs in heart and skeletal muscle" Dr. Da-Zhi Wang, Dept of Cardiology, Children's Hospital Boston University 24 Cummington Street, B01 Boston,MA 02115
Contact: Dr. Chip Celenza
6:00 PM - 9:00 PM
Building and Enriching Your Mentoring Relationships
Description: Program to start at 6:30
MIT Bldg 46, Room 3002 (Singleton Auditorium)
43 Vassar Street, Cambridge, MA 02139
Mentors can enrich your career in many ways and we all have the capacity to also learn by mentoring and teaching others. This program/workshop will introduce the participants to many important skills
• How to find, select and approach a mentor
• How to manage the logistics of a healthy mentoring relationship
• Tools to make your mentoring relationships more productive
• Skills each of us can develop to be better mentors ourselves
Speaker and Workshop Leader: Dr. Joanne Kamens obtained her BA in Biology from the University of Pennsylvania and her Ph.D. in Genetics from Harvard University. She has worked for 20 years in both pharma and biotech drug discovery settings with oligonucleotide, small molecule, and biologic therapeutics. Dr. Kamens has been actively involved in raising awareness of women in science since 1998. She was the founding president of the Massachusetts AWIS chapter and was instrumental in starting the MASS AWIS Mentoring Circle program. She currently serves as the Director of Mentoring for the HBA (Healthcare Business Women’s Association) and is on the Board of Directors for WEST (Women Entrepreneurs in Science and Technology). MASS AWIS Mentoring Committee members will be in attendance to answer questions about the 2011 Mentoring Circle program. Applications for the program are being accepted throughout May and June. New Circles will start meeting in September, 2011.
TO REGISTER AND FOR MORE INFORMATION, VISIT http://www.acteva.com/go/mass-awis or http://www.mass-awis.org/
$10 AWIS members and post-docs/students; $20 for non-members
Join AWIS to save money on events and to support our work!
Contact: Anne-Elise Tobin
Tuesday, May 3, 2011
12:30 PM - 1:30 PM
Cell Fission and Cell Shape Maintenance in E. Coli
Description: Speaker: Piet de Boer, Case Western University School of Medicine
Location: Harvard Med School, Warren Alpert Bldg, Room 341 Host: Dr. Suzanne Walker
Coffee and snacks served at 12:15pm outside the room
Contact: Shannon Humphreys
4:00 PM - 5:00 PM
2011 Gerhard Schmidt Memorial Lecture--“AAA+ Unfoldases: Remodelers of Proteins and the Proteome”
Description: THE 2011 GERHARD SCHMIDT MEMORIAL LECTURE
DR. TANIA A. BAKER, E.C Whitehead Professor of Biology, Massachusetts Institute of Technology, Investigator, Howard Hughes Medical Institute
SACKLER AUDITORIUM, SACKLER BUILDING, 1ST FLOOR, Tufts University, 145 HARRISON AVENUE BOSTON
RECEPTION TO FOLLOW IN SACKLER BUILDING ROOM 216A
Contact: Katie Griffin
4:00 PM - 5:00 PM
Seminars in Oncology: Inflammation and Cancer: Reprogramming Immune Response as an Anti-Cancer Strategy
Description: CHARLES I. SEIGAL MEMORIAL LECTURE
Guest Speaker: Lisa Coussens, University of California San Francisco
Location: Jimmy Fund Auditorium (35 Binney Street)
Hosted by: Kornelia Polyak, MD, PhD, 617-582-7646.
Contact: Claudia Steele
Wednesday, May 4, 2011
Noon - 1:00 PM
Native Antigen Protein Microarrays in Cancer Immunomics and Serum Biomarker Discovery
Description: Brian Liu, Ph.D., Brigham and Women's Hospital
Seminar is at: Auditorium, Boston Biomedical Research Institute, 64 Grove Street, Watertown
Contact: Charles P. Emerson, Jr.
2:00 PM - 3:20 PM
Neurosteroids as Candidate Biomarkers and New Therapeutics
Description: Christine E. Marx, M.D., M.A., Associate Professor, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center and Durham VA Medical Center.

Boston University School of Medicine, 72 East Concord Street, L-112, Boston, MA.

Part of the Current Topics in Pharmacological Sciences Seminar Series sponsored by the Department of Pharmacology & Experimental Therapeutics. Free and open to the public. Refreshments served at 1:45 pm, R-Building 6th Floor.
www.bumc.bu.edu/busm-pm
Contact: Kristina Bigdeli
Thursday, May 5, 2011
Noon - 1:00 PM
DPP2 kd in the hypothalamic VMN leads to obesity and insulin resistance
Description: Location: The Forsyth Institute, 17th Floor, Seminar Room A, 245 First Street, Cambridge
Speaker: Brigitte T. Huber, Tufts University School of Medicine
Summary: The control of glucose metabolism is a complex process, and it is well known that a myriad of neuropeptides and gut hormones play a role in this process. Dysregulation at any level can cause impaired glucose tolerance and insulin resistance. These two defects are well-studied characteristics associated with obesity and onset of type 2 diabetes. We recently discovered a novel regulator of glucose metabolism, the N-terminal dipeptidase DPP2, a vesicular serine protease that has been identified and cloned by the Huber lab. Namely, we observed that conditional knockdown (kd) of DPP2 in all precursors of the gastric tract, pancreas and hypothalamus (NGN3-DPP2 kd) leads to hyperinsulinemia, glucose intolerance and insulin resistance by 4 months of age. Although striking and completely novel, this model system did not allow us to determine whether the diabetes phenotype arose from the lack of DPP2 expression in the central nervous system (CNS) or the gastrointesfinal (Gl) tract. To address this problem, we proceeded to generate SF1-DPP2 kd mice, in which DPP2 is specifically knocked down in a subpopulation of hypothalamic VMN (ventromedial nucleus) neurons, but not in the rest of the hypothalamus, nor in the Gl tract. Our preliminary experiments, assembled by an interdisciplinary investigative team with expertise in the fields of proteomics, molecular biology, neuroanatomy and metabolism, indicate that these mutant mice have a very similar metabolic phenotype as the NGN3-DPP2 kd mice; namely, the SF1-DPP2 kd mice develop hyperinsulinemia, glucose intolerance and insulin resistance, as well as increased body weight, compared to wild type littermates.
Contact: Pam Quattrocchi
4:00 PM - 5:00 PM
The Integration of Adhesion and Signaling Events in Adherens Junctions
Description: Tufts University Program in Cell, Molecular and Developmental Biology Seminar Series.
Guest Speaker: Sergey M. Troyanovsky, PhD, Associate Professor of Dermatology and Cell and Molecular Biology, Northwestern University Feinberg School of Medicine
Location: Tufts Medical Center, Stearns Auditorium, Farnsworth Building, 1st Floor, 800 Washington Street, Boston, MA
There will be a wine and cheese reception immediately following the seminar at Tufts University's M&V Building 5th floor library, 136 Harrison Avenue, Boston, MA
Contact: Sharon Titus
4:30 PM - 5:30 PM
Vascular Biology Seminar:“Microengineered Hydrogels for Stem Cell Bioengineering and Tissue Regeneration”
Description: Microengineered Hydrogels for Stem Cell Bioengineering and Tissue Regeneration
Ali Khademhosseini, Harvard-MIT Division of Health Sciences and Technology, Wyss Institute for Biologically Inspired Engineering, Brigham and Women’s Hospital / Harvard Medical School
Folkman Auditorium, Enders Bldg., Children's Hospital Boston, 320 Longwood Ave.
Contact: David Lynn, 617-525-4351
6:00 PM - 8:30 PM
Work-Life Balance Interactive Program
Description: The Massachusetts Association for Women in Science (Mass-AWIS) announces:
Improving Work-Life Satisfaction
Sponsored by AWIS, Alexion Pharmaceuticals, and the Elsevier Foundation*
Hosted by: Mass-AWIS in connection with the Cambridge Science Festival
The Broad Institute, 7 Cambridge Center Cambridge, MA
Event is open to both men and women. Free to the public, no registration required.
Given the work environments and expectations for women in science, and the fact that a career in science is very often a way of life and far more than a job, work-life balance satisfaction can be elusive. While advocating for change in policies and systems continues to be important, women must find the personal work-life balance strategies that work for them within the systems in which they work. This interactive program will help participants:
• Define for themselves what work-life satisfaction is and is not
• Understand how incongruence between priorities and actions can drain energy and negatively impact work-life satisfaction
• Examine how their current choices impact work-life balance and identify changes that will have the biggest impact on personal and professional satisfaction
• Identify 7 keys to achieving and maintaining work-life satisfaction
• Craft a personalized plan to improve work-life balance satisfaction
In addition, your participation will assist AWIS in advocating on your behalf for improved workplace policies and practices. Mark your calendar to attend this important event.
*This program is provided courtesy of a three-year grant from the Elsevier Foundation. The program will be presented by Masha Hareli, Ph.D, AWIS Massachusetts Chapter President, and Cynthia Simpson, M.Ed, CAE, AWIS Director of Programs and External Relations.
For more information about Mass-AWIS, visit http://www.mass‐awis.org
Contact: Anne-Elise Tobin
Friday, May 6, 2011
8:30 AM - 9:30 AM
MSI Year End Breakfast
Description: MSI Weekly Chalktalk Year End Celebration. Please join us in the Center for the Environment (24 Oxford St, 3rd Floor, Room 310) for a full breakfast hosted by Roberto Kolter (HMS) and Colleen Cavanaugh (OEB).
Contact: Andrea Lenco
1:30 PM - 2:45 PM
Boston University School of Medicine Pathology and Laboratory Medicine Spring 2011 Seminar Series
Description: Guest Speaker: Shyamala Maheswaran, MS, PhD; associate Professor, Department of Surgery; Harvard Medical School. Talk Title: “HOXB9 Expression Promotes Breast Tumor Progression”

Boston University Medical Campus; 670 Albany Street (behind 700 Albany Street); Lobby Level #107/108
Contact: Debbie Kiley
Monday, May 9, 2011
Noon - 1:00 PM
HNRCA Spring Seminar Series with Dr. Trygve Tollefsbol
Description: Join us for a seminar led by Dr. Trygve Tollefsbol. The topic will be "Epigenetics, Aging and Cancer Prevention: The Nutrient Connection".
Location: Jean Mayer USDA HNRCA @ Tufts University, 711 Washington Street, Mezzanine Conference Room, Boston
The event is held in a government building, with security at the front door. In order to gain admittance you will need to bring a government ID to present at the door.
Contact: Christine O'Connell
4:00 PM - 5:00 PM
The 15th Andrew H. Weinberg Lecture
Description: Title of Talk: Childhood Cancer Research: 21st Century Science, 20th Century Clinical Trials
Peter C. Adamson, M.D. Chair, Children’s Oncology Group Chief, Division of Clinical Pharmacology & Therapeutics The Children's Hospital of Philadelphia
Location:Smith Family Room (Dana Building, 16th Fl, Room 1620), Dana-Farber Cancer Institute, 450 Brookline Avenue Boston, MA 02115
Contact: Sarah Hagan
Tuesday, May 10, 2011
8:30 AM - 5:15 PM
McGovern Institute Symposium: Inhibition & Neural Circuit Function
Description: Symposium Schedule
8:30 am Continental breakfast served in atrium
8:45 am - 9:00 am
Robert Desimone and Yingxi Lin, McGovern Institute
Welcoming remarks
Session I (Chair: Martha Constantine-Paton)
9:00 am - 9:45 am
Gordon Fishell (New York University School of Medicine)
The transcription factor SatB1 is essential for the maturation of most Martinotti neurons
9:45 am - 10:30 am
Hollis Cline (The Scripps Research Institute)
Manipulation of inhibition/excitation ratio in vivo disrupts information processing and behavior
10:30 am - 11:00 am
Break
11:00 am - 11:45 am
Chris McBain (National Institute of Child Health & Human Development)
Development and maturation of a hippocampal feedforward inhibitory circuit
11:45 am - 12:30 pm
Josh Huang (Cold Spring Harbor Laboratory)
Toward a genetic dissection of GABAergic circuits in cerebral cortex: chandeliers light up the path
12:30 pm - 1:45 pm
Lunch served in atrium
Session II (Chair: Guoping Feng)
1:45 pm - 2:30 pm
Peter Somogyi (University of Oxford)
Network oscillations and the anatomy of spike timing in the hippocampus
2:30 pm - 3:15 pm
Ed Callaway (Salk Institute for Biological Studies) Rabies-based tools for elucidating neural circuits and linking connectivity to function
3:15 pm - 3:45 pm
Break
3:45 pm - 4:30 pm
Andreas Luthi (Friedrich Miescher Institute for Biomedical Research)
Defining the neuronal circuitry of fear
4:30 pm - 5:15 pm
David Lewis (University of Pittsburgh School of Medicine)
Cortical excitatory/inhibitory balance and cognitive dysfunction in schizophrenia
5:15 pm - 6:45 pm
Reception in atrium
For more information visit http://mcgovern.mit.edu/component/content/article/21-events/457-mcgovern-institute-2011-symposium
Contact: Keren Miller
12:30 PM - 1:30 PM
Understanding Bacterial Transcription Regulation by Studying One Molecule at a Time
Description: Speaker: Jeff Gelles, Brandeis University
Location: Harvard Med School, Warren Alpert Bldg, Room 341
Host: Dr. Ann Hochschild
Coffee and snacks served at 12:15pm outside the room
Contact: Shannon Humphreys
Wednesday, May 11, 2011
2:00 PM - 3:00 PM
Vascular Cognitive Aging
Description: Angela L. Jefferson, Ph.D., Associate Professor of Neurology Director, Education & Information Transfer Core, Alzheimer's Disease Center, Boston University School of Medicine.

Boston University School of Medicine, 72 East Concord Street, L-112, Boston, MA.

Part of the Department of Pharmacology & Experimental Therapeutics Weekly Seminar Series.

Free and open to the public. Refreshments served at 1:45 pm, R-Building 6th Floor.

www.bumc.bu.edu/busm-pm
Contact: Kristina Bigdeli
Thursday, May 12, 2011
4:00 AM - 5:00 AM
2011 MIT Colloquium on the Brain and Cognition - Mapping Olfaction
Description: Speaker: Liqun Luo, PhD Professor, Department of Biology, Stanford University Investigator, Howard Hughes Medical Institute
Place: Singleton Auditorium, 46-3002, MIT
We are interested in studying how neural circuits are organized to process information, and how they are assembled during development. To address these questions, we use Drosophila and mice as model organisms, and combine advanced molecular genetics with developmental, anatomical, physiological and behavioral approaches. We have also developed genetic tools that allow us to answer these questions with more precision. In this talk, I will discuss our recent studies on the organization of olfactory circuits in flies and mice, and mechanisms of olfactory circuit assembly in flies.
Contact: Keren Miller
Noon - 1:00 PM
Interactions of Porphyromonas gingivalis with macrophages ? implications toward atherosclerosis and oral disease
Description: Speaker: Frank C. Gibson III, Ph.D., Boston University Medical Center
Location: The Forsyth Institute, Seminar Room A, 245 First St., 17th Floor, Cambridge
Summary: Porphyromonas gingivalis is a bacterium closely associated with periodontal disease. Clinical data support that periodontal disease may represent reservoir of increased risk for systemic diseases including atherosclerotic cardiovascular disease. Chronic inflammation with complex immune cell infiltration is a hallmark of both periodontal disease and atherosclerosis. Macrophages are present in both diseased periodontal tissues and athromatous plaques; however the precise role these cells play in the pathogenesis of oral and vascular diseases remains incompletely defined. Focusing on the P. gingivalis ? macrophage interaction, our recent studies illuminate potential underlying mechanisms contributing to infection-elicited macrophage lipid uptake. Furthermore, our investigations suggest that macrophage heterogeneity may participate in the inflammatory response to bacteria associated with periodontal disease.
Contact: Pam Quattrocchi
4:30 PM - 5:30 PM
Vascular Biology Seminar:v“Leukocyte Adhesion to Vascular Surfaces Under Flow”
Description: “Leukocyte Adhesion to Vascular Surfaces Under Flow”
Rodger P. McEver, MD, University of Oklahoma Health Sciences Center
Folkman Auditorium, Enders Bldg., Children's Hospital Boston, 320 Longwood Ave.
Contact: David Lynn, 617-525-4351
Friday, May 13, 2011
10:00 AM - 11:00 AM
Monroe Schlesinger Lecture
Description: Monroe Schlesinger Lecture
Speaker: David Baltimore, PhD
Location: The Joseph B. Martin Conference Center, Rotunda, NRB, Beth Israel Deaconess Medical Center, 77 Avenue Louis Pasteur.
Contact: Nicole Magner
Monday, May 16, 2011
Noon - 1:00 PM
HNRCA Spring Seminar Series with Dr. Paul Soloway
Description: Join us for a seminar led by Dr. Paul Soloway. The topic will be "Novel approaches for epigenomic analysis"
Location: Jean Mayer USDA HNRCA @ Tufts University, 711 Washington Street, Mezzanine Conference Room, Boston
The event is held in a government building, with security at the front door. In order to gain admittance you will need to bring a government ID to present at the door.
Contact: Christine O'Connell
Tuesday, May 17, 2011
12:30 PM - 1:30 PM
Why Are Chemotaxis Receptors Clustered but Other Receptors Aren't?
Description: Speaker: Ned S. Wingreen, Princeton University
Location: Harvard Med School, Warren Alpert Bldg, Room 341
Host: Dr. John Mekalanos
Coffee and snacks served at 12:15pm outside the room
Contact: Shannon Humphreys
2:00 PM - 5:00 PM
SWERLING LECTURES 2011: Infectious Causes of Cancer
Description: Guest Speakers Include:
"Why Do Viruses Cause Cancer? Lessons from Merkel Cell Polyomavirus"
Patrick Moore, MD, MPH
"HPV Vaccines: Translating Science into Public Health Policy"
Laura Koutsky, PhD, MSPH
Current and Future HPV Vaccines to Prevent Cervical Cancer and Other HPV-Associated Diseases"
Douglas Lowy, MD
Hosted by: Matthew Meyerson, MD, PhD
http://dfcionline.org/research/oncologyseminars/default.aspx
Contact: Claudia Steele
4:30 PM - 5:30 PM
Seeing Patients: Unconscious Bias in Health Care
Description: Notable Books Series at the Countway Library of Medicine - "Growing up in Jim Crow-era Tennessee and training and teaching in overwhelmingly white medical institutions, Dr. White witnessed firsthand how prejudice works in the world of medicine. And while race relations have changed dramatically, old ways of thinking die hard. Dr. White draws upon his experience in startlingly different worlds to make sense of the unconscious bias that riddles medical treatment, and to explore what it means for health care in a diverse twenty-first century America".
A reception and book signing will follow the lecture
Countway Library of Medicine, Minot Room, 5th floor 10 Shattuck Street, Boston, MA
Contact: Roz Vogel
Wednesday, May 18, 2011
8:30 AM - 5:30 PM
New Frontiers in Neurodegeneration
Description: "New Frontiers in Neurodegeneration"
May 18-19, 2011
Biogen Idec Headquarters (15 Cambridge Center, Building 8) Cambridge, MA
Organized by the UMass Medical School Neurotherapeutics Institute
Sponsored by Biogen Idec and the ALS Therapy Alliance Attendance limited to 200 pre-registered participants. To register, email your contact information to NTI@umassmed.edu
May 18 Speakers:
Robert Brown (UMass Med)
The emerging genetic landscape of ALS
Steven Finkbeiner (UCSF/Gladstone Inst)
Defining neurodegenerative pathways
Li-Huei Tsai (MIT/Picower)
AD, ALS and Aging
Aaron Gitler (UPenn)
Studying protein misfolding diseases in yeast
Eran Hornstein (Weizmann Inst)
MicroRNA malfunction and motor neuron disease
Anthony Antonellis (UMich Med)
tRNAs and neuronal viability
Susan Ackerman (Jackson Labs/HHMI)
Mouse models of neurodegeneration
Timothy Miller (Wash U)
Approaches for gene silencing in ALS therapy
Christopher Henderson (Columbia)
New insights into MN susceptibility in ALS
Kevin Eggan (Harvard/HHMI)
Motor neuron-glia interactions and stem cells
May 19 Speakers:
Marc Freeman (UMass Med/HHMI)
Molecular pathways mediating axon death
Michael Coleman (Babraham Inst)
Axon degeneration and disease
David Rubinsztein (U Cambridge)
Autophagy and neurological disease
Myriam Heiman (MIT/Picower)
TRAPping Huntington's and Parkinson's diseases
Ed Boyden (MIT Media Lab)
Optogenetic manipulation of neuronal circuits
Contact: Melissa Moore
11:30 AM - 1:00 PM
Bioinformatics Seminar Series: Why are chemotaxis receptors clustered but other receptors are not?
Description: Speaker: Ned Wingreen, Princeton
Location: TOC Lab 32-G575 Stata Center, MIT
The chemotaxis network of bacteria such as E. coli is remarkable for its sensitivity to minute relative changes in chemical concentrations in the environment. Indeed, E. coli cells can detect concentration changes corresponding to only ~3 molecules in the volume of a cell. Much of this acute sensitivity can be traced to the collective behavior of teams of chemoreceptors on the cell surface. Instead of receptors switching individually between active and inactive configurations, teams of 6-20 receptors switch on and off, and bind or unbind ligand, collectively.Similar to the binding and unbinding of oxygen molecules by tetramers of hemoglobin, the result is a sigmoidal binding curve. Coupled with a system for adaptation that tunes the operating point to the steep region of this sigmoidal curve, the advantage for chemotaxis is gain i.e., small relative changes in chemical concentrations are transduced into large relative changes in signaling activity (specifically, the rate of phosphorylation of the response regulator CheY). However, something is troubling about this simple explanation: in addition to providing gain, the coupling of receptors into teams also increases noise, and the net result is a decrease in the signal-to-noise ratio of the network. Why then are chemoreceptors observed to form cooperative teams? We present a novel hypothesis that the run-and-tumble chemotactic strategy of bacteria leads to a ³noise treshold², below which noise does not significantly decrease chemotactic velocity, but above which noise dramatically decreases this velocity.
Contact: Patrice Macaluso
Noon - 1:00 PM
2011 Sonis Lecture: "Next Generation Diagnostic Devices Based on Bio-Nano-Chip Sensors: A Step Toward More Affordable Healthcare?"
Description: John T. McDevitt, Rice University 2011 Stephen T. Sonis Visiting Professor
Location: TBA
Contact: Louise Whitehouse
6:00 PM - 7:30 PM
Role of MeCP2 in Regulating Synapse Function and Behavior
Description: Lisa M. Monteggia, Associate Professor, UT Southwestern Medical Center
Please RSVP to lmavros@mit.edu if you'd like to attend.
Visit our website for further details including a talk abstract.
Supported by the Simons Initiative on Autism and the Brain at MIT (web.mit.edu/autism)
Contact: Lee Mavros Rushton
7:00 PM - 8:30 PM
Deadly Medicine in the Nazi Era: What Turned Physician Healers into Killers?
Description: Location: Carl Walter Amphitheatre, Tosteson Medical Education Center, HMS, 260 Longwood Avenue, Boston
Featured speakers:
Patricia Heberer, Ph.D., Historian, Center for Advanced Holocaust Studies, United States Holocaust Memorial Museum
Matthew Wynia, M.D., MPH, Director, Institute for Ethics, American Medical Association
This presentation examines the historical content and legacy of Nazi medicine. It explores the role of the German medical community as planners and implementers of eugenic policies, such as compulsory sterilization and “euthanasia” – the murder of institutionalized patients with disabilities during the Holocaust. The discussion considers the way many German physicians became involved in the criminal action of the Nazi regime and how those activities profoundly affected the development of today’s professional codes and ethics of medicine.
Presented in conjunction with the Boston Medical Library and the Deadly Medicine exhibition produced by the United States Holocaust Memorial Museum - View the exhibit at the Countway Library of Medicine, 10 Shattuck Street, Boston – through July 17th.
This program is free and open to the public, but registration is required. Contact Roz Vogel at rvogel@hms.harvard.edu or call 617.432.4807.
Contact: Roz Vogel
Thursday, May 19, 2011
8:30 AM - 5:30 PM
New Frontiers in Neurodegeneration
Description: "New Frontiers in Neurodegeneration" May 18-19, 2011 Biogen Idec Headquarters (15 Cambridge Center, Building 8) Cambridge, MA Organized by the UMass Medical School Neurotherapeutics Institute Sponsored by Biogen Idec and the ALS Therapy Alliance Attendance limited to 200 pre-registered participants. To register, email your contact information to NTI@umassmed.edu May 18 Speakers: Robert Brown (UMass Med) The emerging genetic landscape of ALS Steven Finkbeiner (UCSF/Gladstone Inst) Defining neurodegenerative pathways Li-Huei Tsai (MIT/Picower) AD, ALS and Aging Aaron Gitler (UPenn) Studying protein misfolding diseases in yeast Eran Hornstein (Weizmann Inst) MicroRNA malfunction and motor neuron disease Anthony Antonellis (UMich Med) tRNAs and neuronal viability Susan Ackerman (Jackson Labs/HHMI) Mouse models of neurodegeneration Timothy Miller (Wash U) Approaches for gene silencing in ALS therapy Christopher Henderson (Columbia) New insights into MN susceptibility in ALS Kevin Eggan (Harvard/HHMI) Motor neuron-glia interactions and stem cells May 19 Speakers: Marc Freeman (UMass Med/HHMI) Molecular pathways mediating axon death Michael Coleman (Babraham Inst) Axon degeneration and disease David Rubinsztein (U Cambridge) Autophagy and neurological disease Myriam Heiman (MIT/Picower) TRAPping Huntington's and Parkinson's diseases Ed Boyden (MIT Media Lab) Optogenetic manipulation of neuronal circuits
Contact: Melissa Moore
1:00 PM - 8:00 PM
Bergey's International Society for Microbial Systematics
Description: The study of Microbial Systematics is linked to several important areas of scientific research:
• Technological advances that can greatly improve research
• Bacterial, archaeal and eukaryotic diversity studies
• Guided biotechnology and drug discovery
The first Inaugural meeting of Bergey’s International Society for Microbial Systematics will provide a dedicated event for microbial systematics and associated research, at the Friendship Hotel, Beijing, China, from May 19th-23rd, 2011.
Scientists who attend this conference have the opportunity to; learn how systematics influences studies in diversity, genetics, enzymatic and industrial potentials, and the current technologies available to improve this research; exchange knowledge and ideas, and improve personal and professional global communication and networks. In addition a Young Scientist Forum will be held for young researchers (under age 35) as an opportunity to showcase their work. Poster and industrial presentations will also be running.
Unique and exciting features of BISMiS 2011:
• We already have registered scientists from 21 different countries
• Opening keynote presentation ‘Drug discovery from microbial nature products’- Nobel Prize Laureate Dr. Barry Sharpless, Scripps Institute, California, USA
• Bioinformatics workshop ‘Next generation sequencing’ Prof. Jongsik Chun School of Biological Sciences, Seoul National University, Korea
• Discussion on the future criteria for the Characterization of Prokaryotes, vital information for anyone wanting to successfully publish taxonomic information in the future
For more information, to register, and to submit an abstract, visit our website at WWW.BISMiS.org. To manage increased interest from the scientific community we are extending the abstract submission deadline to 31th March 2011.
This three-day conference will bring together scientists and academic leaders from research institutions, as well as pharmaceutical companies in one highly interactive event. The organizers of BISMiS 2011 are two of the biggest supporters of Microbial Systematics in the world:
• Bergey’s Manual Trust- the absolute authority in the field of microbial systematics
• Chinese Society of Microbiology- whose diverse research covers science and technology in the fields of industry, agriculture, medicine, environmental protection, national defense etc.
http://www.bismis.org
Contact: Dr Elizabeth Ashforth
5:30 PM - 9:00 PM
"Women Don't Ask": Effective Negotiation Strategy Workshop
Description: Whether they want higher salaries, enhanced career opportunities, or more help at home, women are much less likely than men to ask for what they want. This workshop will explore the causes of women's propensity to avoid negotiating and look at "best practice" negotiation principles within the framework of the issues that impact women. It will show you how to recognize more opportunities to negotiate, set the right targets, and remain unfazed by the emotional dimensions of the interaction. Workshop leader:
•Sara Laschever, co-author of Ask For It: How Women Can Use the Power of Negotiation To Get What They Really Want and Women Don't Ask: The High Cost of Avoiding Negotiation and Positive Strategies for Change
WEST would like to thank IBM Center for Social Software for their generous support of this event
http://www.westorg.org/mc/page.do?sitePageId=125152
Contact: Susan Silberman
Tuesday, May 24, 2011
12:30 PM - 1:30 PM
Exploring and Engineering Human Immunity Using Small Molecules
Description: Speaker: David Spiegel, Yale University
Location: Harvard Med School, Warren Alpert Bldg, Room 341
Host: Dr. Priscilla Yang
Coffee and snacks served at 12:15 pm outside the room
Contact: Shannon Humphreys
Thursday, May 26, 2011
Noon - 1:00 PM
State of the Union between metabolism and the immune system in type 2 diabetes
Description: Speaker: Barbara Nikolajczyk, Boston University School of Medicine
Location: The Forsyth Institute, Seminar Room A, 245 First St., 17th Floor, Cambridge
Summary: The relatively recent appreciation of obesity, insulin resistance and type 2 diabetes (T2D) as chronic inflammatory diseases has stimulated interest in understanding the role immune cells play in metabolic imbalance. Myeloid cells regulate inflammation through cytokine production and the adipose tissue remodeling that accompanies hyper-nutrition, thus are critical players in metabolic homeostasis. More recent studies have indicated a role for T cells in obesity-associated inflammation and insulin resistance in model organisms, with parallel with our work indicating that pro-inflammatory changes in T cells also associate with human T2D. Parallel pro-inflammatory changes in the B cell compartment of T2D patients have also been identified. Taken together, these studies indicate that, in addition to accepted pro-inflammatory roles of myeloid cells in T2D, pro-inflammatory skewing of both major lymphocyte subsets plays an important role in T2D disease pathogenesis. We propose a model for inflammation in T2D that functionally links lymphocyte, myeloid and adipocyte contributions and, importantly, proposes that immunomodulatory drugs may have a place in the Endocrinologist’s limited arsenal.
Contact: Pam Quattrocchi
4:00 PM - 5:00 PM
Regulation of Epithelial Polarity by the PAR Complex
Description: Tufts University Program in Cell, Molecular and Developmental Biology Seminar Series
Guest Speaker: Tony Harris, PhD, Department of Cell and Systems Biology, University of Toronto
Location: Tufts University Behrakis Auditorium, The Jaharis Family Center for Biomedical and Nutritional Sciences, 150 Harrison Avenue, Boston
There will be a wine and cheese reception immediately following the seminar in the 5th floor library at 136 Harrison Avenue, Boston
Contact: Sharon Titus
4:30 PM - 5:30 PM
Vascular Biology Seminar: Third Annual Judah Folkman, MD Lecture
Description: Patricia A. D’Amore, Schepens Eye Research Institute
Third Annual Judah Folkman, MD Lecture “The Many Roles of VEGF in the Adult”
Reception to Follow Lecture
Folkman Auditorium, Enders Building, Children's Hospital Boston, 320 Longwood Ave.
Contact: David Lynn, 617-525-4351
Tuesday, May 31, 2011
4:00 PM - 5:00 PM
Generating cardiomyocytes from human pluripotent stem cells
Description: Cardiovascular Seminar Series
Gordon M. Keller, University Health Network
  Folkman Auditorium, John F. Enders Research Bldg., Children’s Hospital Boston
This conference is supported by the Faye and Karen Sinclair Research Fund for Congenital Heart Disease
Contact: Michelle Merry
4:00 PM - 5:00 PM
Special Seminar--DNA makes RNA makes heterochromatin: silencing in fission yeast
Description: Hiten Madhani, UCSF Location: McGovern Auditorium, Whitehead Institute
Contact: Laura Resteghini
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