Speaker: S. Adam Hacking, Ph.D., Director, Laboratory for Musculoskeletal Research and Innovation Orthopaedics, MGH
Location: The Forsyth Institute, Seminar Rooms A & B, 245 First Street, 17th Floor, Cambridge
Summary: For over 20 years, the application of micro and nano-sized features to the surface of titanium implants has been recognized as a predictable means to enhance osseointegration. Worldwide, dental and orthopaedic devices with textured surfaces are implanted over 500,000 times annually. Given the extent and duration of clinical use, it is surprising that a biologic rationale for action has not been proposed. My group is interested in biomimetic cues that guide tissue repair. We considered regions and features associated with bone formation and determined that osteoclast resorption pits and the fracture surfaces were candidates for study. In this seminar, I will present data that suggests the osseous response to textured implant surfaces may in fact be part of a programmed response to the fracture surface of bone. By taking morphological cues from the fracture surface, we have modified the native ‘smooth’ surface of cortical and cancellous bone to include micro and nano-sized features. We have produced engineered bone surfaces that increase the extent of new bone formation in rat and rabbit animal models.
This presentation will provide a review of the fundamentals of surface topography measurement, recent advances in techniques to evaluate the osseous response to biomaterials and will provide data from in vivo and in vitro studies.