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Bioweek
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4:30 PM - 5:30 PM Romania's Abandoned Children: Deprivation, Brain Development, and the Struggle for Recovery

5:00 PM - 7:00 PM Microbial Sciences Initiative (MSI) Undergraduate Fellows Poster Session

8:30 AM - 5:00 PM 29th Annual Critical Issues in Tumor Microenvironment, Angiogenesis, Metastasis and Immunology

4:00 PM - 5:00 PM Genes, networks and variations in innate immunity

8:30 AM - 5:00 PM 29th Annual Critical Issues in Tumor Microenvironment, Angiogenesis, Metastasis and Immunology

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8:30 AM - 5:00 PM 29th Annual Critical Issues in Tumor Microenvironment, Angiogenesis, Metastasis and Immunology

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8:30 AM - 5:00 PM 29th Annual Critical Issues in Tumor Microenvironment, Angiogenesis, Metastasis and Immunology

2:00 PM - 5:30 PM Warren Alpert Foundation Prize Symposium: Neurotransmission in Health and Disease

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Tuesday, September 16, 2014
4:30 PM - 5:30 PM
Romania's Abandoned Children: Deprivation, Brain Development, and the Struggle for Recovery
Description: NOTABLE BOOKS SERIES AT THE COUNTWAY LIBRARY OF MEDICINE

Location: COUNTWAY LIBRARY OF MEDICINE, MINOT ROOM, 10 SHATTUCK STREET, BOSTON

SPEAKER: Charles A. Nelson III, PhD, Professor of Pediatrics & Professor of Psychology in Psychiatry, HMS Richard David Scott Chair in Pediatric Developmental Research, Boston Children's Hospital

Topic - “The implications of early experience for children's brain development, behavior, and psychological functioning have long absorbed caregivers, researchers, and clinicians. The 1989 fall of Romania's Ceausescu regime left approximately 170,000 children in 700 overcrowded, impoverished institutions across Romania, and prompted the most comprehensive study to date on the effects of institutionalization on children's well-being. Romania's Abandoned Children, the authoritative account of this landmark study, documents the devastating toll paid by children who are deprived of responsive care, social interaction, stimulation, and psychological comfort”.

www.countway.harvard.edu
Contact: Roz Vogel
Wednesday, September 17, 2014
5:00 PM - 7:00 PM
Microbial Sciences Initiative (MSI) Undergraduate Fellows Poster Session
Description: Location: Seminar Room, Harvard University Center for the Environment, (24 Oxford St., Cambridge)
Refreshments will be served!
Contact: Nora Millan Rivas
Monday, September 29, 2014
8:30 AM - 5:00 PM
29th Annual Critical Issues in Tumor Microenvironment, Angiogenesis, Metastasis and Immunology
Description: Approval of multiple molecularly targeted agents for therapy of cancer and other diseases has heralded a new era. For tumor biology, the major challenges in the field are now how to optimally use these novel drugs as monotherapies or in combination with other therapies to extend the survival advantage obtained so far, and how to prevent tumor recurrence. These may be best achieved by bringing back and forth between bench and bedside the lessons and the new concepts that emerged from the recent clinical and preclinical experience with molecularly targeted agents. The objective of this course is to discuss our current understanding of tumor microenvironment, the formation and function of new vessels in tumors, and their relationship with metastasis and outcome of various treatments. The focus will be placed on their pathophysiological significance and clinical relevance, with particular emphasis on clinical translation and biomarkers. At the end of this course participants will be able to: Evaluate molecularly targeted agents and immunotherapies approved or currently in clinical development for cancer treatment. Assess relevant, state-of-the-art or translational pre-clinical models of anti-cancer therapies. Recognize the steps and determinants of the metastatic process of cancer. Compare correlative studies of biomarkers and their response and resistance to targeted therapies in cancer patients. Analyze state of the art imaging techniques and their applications in pre-clinical and clinical studies will be taught. Accreditation Harvard Medical School is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Harvard Medical School designates this educational activity for a maximum of 24 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.
Contact: Rakesh K. Jain, PhD
4:00 PM - 5:00 PM
Genes, networks and variations in innate immunity
Description: MGH/Harvard Cutaneous Biology Research Center Seminar Series

Nir Hacohen, PhD Associate Professor of Medicine, Massachusetts General Hospital Center for Immunology and Inflammatory Diseases
MGH-East -- Building 149 13 Street, Charlestown Navy Yard, 7th floor, Isselbacher Auditorium
Registration at Lobby Security Desk Required
Contact: Vivian Theodoracopoulos
Tuesday, September 30, 2014
8:30 AM - 5:00 PM
29th Annual Critical Issues in Tumor Microenvironment, Angiogenesis, Metastasis and Immunology
Description: Approval of multiple molecularly targeted agents for therapy of cancer and other diseases has heralded a new era. For tumor biology, the major challenges in the field are now how to optimally use these novel drugs as monotherapies or in combination with other therapies to extend the survival advantage obtained so far, and how to prevent tumor recurrence. These may be best achieved by bringing back and forth between bench and bedside the lessons and the new concepts that emerged from the recent clinical and preclinical experience with molecularly targeted agents. The objective of this course is to discuss our current understanding of tumor microenvironment, the formation and function of new vessels in tumors, and their relationship with metastasis and outcome of various treatments. The focus will be placed on their pathophysiological significance and clinical relevance, with particular emphasis on clinical translation and biomarkers. At the end of this course participants will be able to: Evaluate molecularly targeted agents and immunotherapies approved or currently in clinical development for cancer treatment. Assess relevant, state-of-the-art or translational pre-clinical models of anti-cancer therapies. Recognize the steps and determinants of the metastatic process of cancer. Compare correlative studies of biomarkers and their response and resistance to targeted therapies in cancer patients. Analyze state of the art imaging techniques and their applications in pre-clinical and clinical studies will be taught. Accreditation Harvard Medical School is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Harvard Medical School designates this educational activity for a maximum of 24 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.
Contact: Rakesh K. Jain, PhD
Wednesday, October 1, 2014
8:30 AM - 5:00 PM
29th Annual Critical Issues in Tumor Microenvironment, Angiogenesis, Metastasis and Immunology
Description: Approval of multiple molecularly targeted agents for therapy of cancer and other diseases has heralded a new era. For tumor biology, the major challenges in the field are now how to optimally use these novel drugs as monotherapies or in combination with other therapies to extend the survival advantage obtained so far, and how to prevent tumor recurrence. These may be best achieved by bringing back and forth between bench and bedside the lessons and the new concepts that emerged from the recent clinical and preclinical experience with molecularly targeted agents. The objective of this course is to discuss our current understanding of tumor microenvironment, the formation and function of new vessels in tumors, and their relationship with metastasis and outcome of various treatments. The focus will be placed on their pathophysiological significance and clinical relevance, with particular emphasis on clinical translation and biomarkers. At the end of this course participants will be able to: Evaluate molecularly targeted agents and immunotherapies approved or currently in clinical development for cancer treatment. Assess relevant, state-of-the-art or translational pre-clinical models of anti-cancer therapies. Recognize the steps and determinants of the metastatic process of cancer. Compare correlative studies of biomarkers and their response and resistance to targeted therapies in cancer patients. Analyze state of the art imaging techniques and their applications in pre-clinical and clinical studies will be taught. Accreditation Harvard Medical School is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Harvard Medical School designates this educational activity for a maximum of 24 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.
Contact: Rakesh K. Jain, PhD
Thursday, October 2, 2014
8:30 AM - 5:00 PM
29th Annual Critical Issues in Tumor Microenvironment, Angiogenesis, Metastasis and Immunology
Description: Approval of multiple molecularly targeted agents for therapy of cancer and other diseases has heralded a new era. For tumor biology, the major challenges in the field are now how to optimally use these novel drugs as monotherapies or in combination with other therapies to extend the survival advantage obtained so far, and how to prevent tumor recurrence. These may be best achieved by bringing back and forth between bench and bedside the lessons and the new concepts that emerged from the recent clinical and preclinical experience with molecularly targeted agents. The objective of this course is to discuss our current understanding of tumor microenvironment, the formation and function of new vessels in tumors, and their relationship with metastasis and outcome of various treatments. The focus will be placed on their pathophysiological significance and clinical relevance, with particular emphasis on clinical translation and biomarkers. At the end of this course participants will be able to: Evaluate molecularly targeted agents and immunotherapies approved or currently in clinical development for cancer treatment. Assess relevant, state-of-the-art or translational pre-clinical models of anti-cancer therapies. Recognize the steps and determinants of the metastatic process of cancer. Compare correlative studies of biomarkers and their response and resistance to targeted therapies in cancer patients. Analyze state of the art imaging techniques and their applications in pre-clinical and clinical studies will be taught. Accreditation Harvard Medical School is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Harvard Medical School designates this educational activity for a maximum of 24 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.
Contact: Rakesh K. Jain, PhD
2:00 PM - 5:30 PM
Warren Alpert Foundation Prize Symposium: Neurotransmission in Health and Disease
Description: Neurotransmission in Health and Disease

In honor of Oleh Hornykiewicz, MD, Roger A. Nicoll, MD, Solomon H. Snyder, MD for their seminal contribution to our understanding of neuro transmission and Neurodegeneration.

Harvard Medical School, The Joseph B.Martin Conference Center, 77 Avenue Louis Pasteur, Boston

Open to the public: RSVP to HMS_events@hms.harvard.edu

Symposium Program

Opening Remarks:
Jeffrey S. Flier, MD, Dean of Faculty, Harvard Medical School

Co-Moderators:
Rachel Wilson, PhD,Professor, Department of Neurobiology, Harvard Medical School

David Ginty, PhD, Edward R. and Anne G. Lefler Professor of Neurobiology, HMS, Investigator, Howard Hughes Medical Institute

Prize Recipients

Remarks and Reflections:
Oleh Hornykiewicz, MD, Professor Emeritus Medical University of Vienna and University of Toronto

Solomon H. Snyder, MD, Distinguished Service Professor of Neuroscience, Pharmacology and Psychiatry, Johns Hopkins School of Medicine

Roger A. Nicoll, MD, Professor, University of California, San Francisco School of Medicine

Invited Speakers:
John Williams, PhD, Senior Scientist, Vollum Institute Oregon Health & Sciences University
"G-protein Coupled Receptor dependent synaptic transmission"

Anatol Kreitzer, PhD, Associate Investigator, Gladstone Institutes, University of California, San Francisco
"Circuit Mechanisms Underlying Basal Ganglia Function and Dysfunction"

Beth Stevens, PhD, Assistant Professor, FM Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School
"Immune Mechanisms of Synapse Loss in Health and Disease"
Contact: Edward Canton
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