| Monday, April 29, 2013
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Noon - 1:00 PM
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| Tuesday, April 30, 2013
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Noon - 1:00 PM
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Novel biomimetic “spiny” and “slippery” surfaces in medical applications
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| Description: |
Speaker: Joanna Aizenberg, Ph.D
A. S. Berylson Professor of
Material Sciences at Harvard's
School of Eng../Applied Sciences
Prof. of Chemistry and Chemical
Biology/ Dept/Chem. & Chem. Bio.
Director/Science Prog./Radcliffe
Institute/Advanced Study, Harvard
Co-Director of the Kavli Institute for
Bionano Science & Tech., Harvard
Location: The Forsyth Institute, Seminar Rms. A & B
245 First Street, 17th Floor
Cambridge
Abstract: The ability of organisms to respond to various stimuli provides an inspiration for a modern engineering and science that seek to develop a new generation of materials with dynamic, adaptive properties. I will describe the synthesis, fabrication and characterization of new hybrid nano/micro-structures that mimic the echinoderm skin and surfaces of carnivorous plants. We demonstrate that these surfaces can be reversibly actuated and assembled into a variety of previously unseen structures with uniform, periodic or chiral nano/micro-patterns. The application of these novel substrates as a multifunctional platform for controlling mammalian and bacterial cell patterning, differentiation and function, as well as an excellent anti-biofouling material will be described.
Educational/Learning Ojectives: pursues a broad range of research including biomimetics, self-assembly, smart materials, crystal engineering, surface chemistry, nanofabrication, biomineralization, biomechanics and biooptics
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| Contact: |
Pam Quattrocchi
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12:30 PM - 1:30 PM
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2:00 PM - 3:00 PM
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Informal Seminar with Yoav Soen
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| Description: |
"Epigenetic and Symbiotic Responses to Toxic Stress-Mechanisms and Transgeneral Implications
Yoav Soen
Tuesday, April 30
2:00pm
McGovern Auditorium
Whitehead Institute
9 Cambridge Center, Cambridge
Hosted by Rudolf Jaenisch
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| Contact: |
Gerry Kemske
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| Wednesday, May 1, 2013
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11:00 AM - Noon
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11:30 AM - 1:00 PM
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Bioinformatics Seminar Series: Sparse learning methods for dissecting the genetic control of biological systems
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| Description: |
Seyoung Kim,CMU
Location: TOC Lab Stata Center 32-G575, MIT
Since the completion of genome sequencing projects for various organisms including human and other model organisms, the fundamental goal of research in computational genomics, systems biology, and genetics has been to gain a complete understanding of how the instruction sets encoded in genomes get executed within a cell system and organism. The recent advances in the high-throughput technology such as next-generation sequencing technology have allowed the researchers to collect a large amount of data for the genomes and various other aspects of a cell system. Such datasets hold the key to understanding the detailed mechanisms of the genetic control of a biological system and further deepening our knowledge of cell biology with a potential application to medicine.
In this talk, I will present statistical machine learning methods that we have developed for learning from high-dimensional genomic data to dissect the genetic control of biological systems. I will focus on sparse learning methods that range from sparse regression methods to sparse probabilistic graphical models, and describe how such methods can be used to effectively extract complex epistatic and pleiotropic interactions among various entities in a biological system. In addition, I will discuss efficient optimization algorithms for learning these statistlcal models that allow for analysis of large-scale genome-wide datasets. Using yeast genotype and gene-expression dataset, I will demonstrate how our methods can lead to new insights into the activities of genes in a cell as well as the perturbations of gene expressions by genetic variation.
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| Contact: |
Patrice Macaluso
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Noon - 1:00 PM
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| Thursday, May 2, 2013
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Noon - 1:00 PM
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"The Mechanism of Synchronous Release of Neurotransmitters at Synapses"
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| Description: |
2013 Don W. Fawcett Lectures in Cell Biology
Speaker: James E. Rothman, Ph.D., Fergus F. Wallace Professor of the Biomedical Sciences, Chairman of the Yale School of Medicine’s Department of Cell Biology, Director and Founder of the Nanobiology Institute, Yale west campus,Yale School of Medicine
LOCATION: Armenise Amphitheater (Building D), 210, Harvard Medical School, Longwood Avenue, Boston
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| Contact: |
Deborah Hull
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Noon - 1:00 PM
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Seq'ing understanding of Porphyromonas virulence
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| Description: |
Speaker: Linden Hu, MD, Vice Chairman for Faculty Development, Dept. of Medicine, Tufts Medical Center Professor, Tufts University School of Medicine
Location: The Forsyth Institute, Seminar Room A, 245 First St., 17th Floor, Cambridge
Abstract: This presentation will review our recent work in developing a transposon library in Porphyromonas gingivalis and in probing this library using massively parallel sequencing techniques to identify essential genes as well as novel genes important in antibiotic resistance and nutrient acquisition. This presentation will also discuss identification of specific probiotic strains of bacteria that may inhibit growth of P. gingivalis
Educational objectives:
1. understand how massively parallel sequencing can be utilized to study transposon libraries of microbial pathogens
2. understand the characterization of essential genes of P. gingivalis.
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| Contact: |
Pam Quattrocchi
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| Friday, May 3, 2013
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Noon - 1:00 PM
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"Protein Dynamics in the Golgi Apparatus"
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| Description: |
James E. Rothman, Ph.D., Fergus F. Wallace Professor of the Biomedical Sciences, Chairman of the Yale School of Medicine’s Department of Cell Biology, Director and Founder of the Nanobiology Institute, Yale west campus, Yale School of Medicine
LOCATION: Armenise Amphitheater (Building D), 210, Harvard Medical School, Longwood Avenue, Boston
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| Contact: |
Deborah Hull
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2:00 PM - 3:00 PM
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Pathology Seminar Series
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| Description: |
Pathology Seminar Series
Dr. Dean Tang, The University of Texas MD Anderson Cancer Center
Location: CLS (Center Life Sciences), Room 421, 3 Blackfan Circle, Boston
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| Contact: |
Cristina Bonilla
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| Monday, May 6, 2013
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9:00 AM - 5:00 PM
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Joslin Symposium: Challenges and Opportunities in Type 1 Diabetes Research
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| Description: |
On Monday, May 6, 2013, Joslin will host the inaugural Joslin Symposium on the campus of Harvard Medical School. The topic will be Type 1 diabetes, with a focus on defining scientific and therapeutic opportunities and challenges. The one-day symposium will cover a wide range of areas of importance for improving and developing Type 1 therapies, including Type 1 immunology, beta cell replenishment, closed-loop insulin pumps, and clinical trials. A stellar group of eight internationally-known scientific leaders have agreed to speak, and ample time will be allotted for questions, discussion, and scientific interactions. We anticipate that this will be an exciting day for the Harvard, Boston, and international Type 1 diabetes research communities.
Speakers:
Edward Damiano
Andrew Stewart
Diane Mathis
Emil Unanue
Doug Melton
Matthias von Herrath
Jay Skyler
Susan Bonner-Weir
Topics:
Biological and Mechanical Beta-cell Replacement Strategies in Type 1 Diabetes
Interventions to Halt Beta-cell Destruction and Type 1 Diabetes
Harnessing Stem Cells: Potential Cure for Type 1 Diabetes
New Insights into Autoimmunity
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| Contact: |
Kay Holt
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Noon - 1:00 PM
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| Tuesday, May 7, 2013
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9:00 AM - 5:30 PM
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Neural Control of Appetite LabLinks - Registration is now open
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| Description: |
Cell Press LabLinks are FREE, one-day symposia organized by scientists in conjunction with Cell Press editors. Each LabLinks features local and keynote speakers discussing a unified topic in order to foster interactions between colleagues working on related questions–whether those colleagues are across town, across the street, or even across the hall.
LabLinks are FREE! Seating is limited, and preregistration is strongly recommended.
Current Meeting: Neural Control of Appetite
This meeting will focus on neural and neuro-endocrine mechanisms underlying food regulation. Talks will offer an interesting array of molecular, cellular, and therapeutic perspectives and will cover a wide range of topics, including technology creation; the manipulation of neurocircuits that regulate feeding behavior; ER stress, inflammation, and leptin resistance; and changes in metabolic responses after bariatric surgery. We hope that scientists who might not normally interact will come together to explore the common ground between these areas.
Folkman Auditorium, Enders Building, Boston Children’s Hospital, Boston, MA
Organizers:
Effie Tzameli, Associate Editor, Trends in Endocrinology and Metabolism
Ann Goldstein, Scientific Editor, Neuron
Umut Ozcan, Boston Children’s Hospital and Harvard Medical School
Keynote Speaker:
Jeffrey Friedman, Rockefeller University
Meeting Program:
9:00am – 10:15am
Ronald Lechan, Tufts Medical Center
Heterogenity and Functional Characterization of Melanocortin-Producing Neurons in the Hypothalamic Arcuate Nucleus
Brad B. Lowell, Beth Israel Deaconess Medical Center and Harvard Medical School
Using Cre-Enabled, Neuron-Specific Approaches to Map and Manipulate Neurocircuits Regulating Feeding Behavior
10:15am – 10:30am
Coffee Break
10:30am – 12:00pm
Umut Ozcan, Boston Children’s Hospital and Harvard Medical School
ER Stress, Inflammation and Leptin Resistance
Maribel Rios, Tufts University School of Medicine
Mechanisms Underlying the Central Effects of BDNF on Feeding
Gorica Petrovich, Boston College
Forebrain Networks and the Control of Feeding by Learned Environmental Cues
12:00pm – 1:15pm
Lunch (on your own)
1:15pm – 3:10pm
Keynote Address
Jeffrey Friedman, Rockefeller University
Studies of the Neural Circuit Regulating Food Intake
Matthias H. Tschöp, HelmholtzZentrum München, Germany
Targeting the Neuroendocrine Control of Food Intake for the Treatment of the Metabolic Syndrome
Laura Holsen, Brigham and Women's Hospital and Harvard Medical School
The Hypothalamus and Beyond: Neural and Hormonal Pathways Governing Human Appetite
3:10pm – 3:30pm
Coffee Break
3:30pm – 5:30pm
Tamas L. Horvath, Yale School of Medicine
Hypothalamic Hunger-Promoting Neurons Regulate Higher Brain Functions and Longevity
Lee Kaplan, Massachusetts General Hospital and Harvard Medical School
Metabolic Responses to Bariatric Surgery
Jens Brüning, Institute for Experimental Genetics, University of Cologne, Germany
CNS-Dependent Control of Feeding and Glucose Metabolism
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| Contact: |
Effie Tzameli
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4:00 PM - 5:00 PM
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| Wednesday, May 8, 2013
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Noon - 1:00 PM
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| Monday, May 13, 2013
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5:30 PM - 6:45 PM
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The FDA and the Remaking of Modern Clinical Research
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| Description: |
The Boston Medical Library in the Countway Library of Medicine presents the J. Worth Estes, MD History of Medicine lecture.
This year's speakjer is Dr Daniel Carpenter, Allie S. Freed Professor of Government and Director of the Center for American Political Studies at Harvard University. Dr. Carpenter is the author of Reputation and Power: Organizational Image and Pharmaceutical Regulation at the FDA (Princeton 2010) and received the 2011 Allan Sharlin Memorial Award from the Social Science History Association. In his lecture he will touch upon “how the FDA cultivated a reputation for competence and vigilance throughout the last century, and how this organizational image has enabled the agency to regulate an industry as powerful as American pharmaceuticals while resisting efforts to curb its own authority. He explains how the FDA's reputation and power have played out among committees in Congress, and with drug companies, advocacy groups, the media, research hospitals and universities, and governments in Europe and India. He shows how FDA regulatory power has influenced the way that business, medicine, and science are conducted in the United States and worldwide. Along the way, Carpenter offers new insights into the therapeutic revolution of the 1940s and 1950s; the 1980s AIDS crisis; the advent of oral contraceptives and cancer chemotherapy; the rise of antiregulatory conservatism; and the FDA's waning influence in drug regulation today”.
Armenise Amphitheatre, Harvard Medical School, 200 Longwood Avenue, Boston, MA
rsvp to Roz Vogel at rvogel@hms.harvard.edu
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| Contact: |
Roz Vogel
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| Friday, May 24, 2013
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10:00 AM - 11:00 AM
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Monroe Schlesinger Lecture 2013
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| Description: |
Department of Pathology at BIDMC presents: The Monroe Schlesinger Lecture
Speaker: Channing J. Der, PhD, Sarah Graham Kenan Distinguished Professor, University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center
The Joseph B. Martin Conference Center Rotunda
The New Research Building, 77 Avenue Louis Pasteur
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| Contact: |
Nicole Magner
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Month of May 2013
