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Bioweek
Sun Mon Tue Wed Thu Fri Sat
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8:30 AM - 5:30 PM Rethinking the Response to Emerging Microbes: Vaccines and Therapeutics in the Ebola Era

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8:30 AM - 9:30 AM Microbial Sciences Initiative (MSI) Chalktalk: F. Ausubel

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4:00 PM - 5:00 PM Multifaceted Functions Of The PD-1 Pathway

11:30 AM - 1:00 PM Bioinformatics Seminar Series: Massive migration from the Eurasian steppe was a source for Indo-European languages in Europe

6:00 PM - 7:00 PM Microbial Sciences Initiative (MSI) Seminar: P. Levin

11:30 AM - 1:00 PM Bioinformatics Seminar Series:Evolutionary couplings: causal relationships for discovery and design

3:00 PM - 4:00 PM Distinguished Lecture Series: Regenerative medicine - a breakthrough way of thinking about disease and injury, using a process that can signal the body to rebuild itself

8:30 AM - 9:30 AM Microbial Sciences Initiative (MSI) Chalktalk: C. Vidoudez

12:30 PM - 1:30 PM An outer membrane lipoprotein detects envelope stress by monitoring β-barrel assembly

8:30 AM - 9:30 AM Microbial Sciences Initiative (MSI) Seminar: L. Vandenberghe

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8:30 AM - 9:30 AM Microbial Sciences Initiative (MSI) Chalktalk: A. Cantley

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Thursday, March 5, 2015
8:30 AM - 5:30 PM
Rethinking the Response to Emerging Microbes: Vaccines and Therapeutics in the Ebola Era
Description: For more information please visit http://hms.harvard.edu/ebola-forum-2015

RSVP by March 1, 2015: EbolaForum@hms.harvard.edu

Harvard Medical School, The Joseph B. Martin Conference Center, The New Research Building, HMS, 77 Avenue Louis Pasteur, Boston, MA 02115
Contact: Jessica Conner
Friday, March 6, 2015
8:30 AM - 9:30 AM
Microbial Sciences Initiative (MSI) Chalktalk: F. Ausubel
Description: Title: P. aeruginosa antibiotic resistance and virulence-blocking compounds
Speaker: Fred Ausubel (HMS-MGH)
Location: HUCE Seminar Room 310 (24 Oxford St, 3rd Floor, Cambridge)
Host: Colleen Cavanaugh
Contact: Nora Millan Rivas
Monday, March 9, 2015
4:00 PM - 5:00 PM
Multifaceted Functions Of The PD-1 Pathway
Description: MGH/Harvard Cutaneous Biology Research Center Seminar Series
Arlene H. Sharpe, MD, PhD, George Fabyan Professor of Comparative Pathology, Harvard Medical School

MGH East Building 149 13th Street, Charlestown Navy Yard Isselbacher Auditorium 7th Floor
Registration at Lobby Security Desk Required
Refreshments available prior to start of talk
Contact Person: Vivian Theodoracopoulos
Contact E-mail: vtheodoracopoulos@partners.org
Contact: Vivian Theodoracopoulos
Wednesday, March 11, 2015
11:30 AM - 1:00 PM
Bioinformatics Seminar Series: Massive migration from the Eurasian steppe was a source for Indo-European languages in Europe
Description: Speaker: David Reich , Harvard Medical School
Location: 32-G575, MIT

We generated genome-wide data from 69 Europeans who lived between 8,0003,000 years ago by enriching ancient DNA libraries for a target set of almost 400,000 polymorphisms. Enrichment of these positions decreases the sequencing required for genome-wide ancient DNA analysis by a median of around 250-fold, allowing us to study an order of magnitude more individuals than previous studies and to obtain new insights about the past. We show that the populations of Western and Far Eastern Europe followed opposite trajectories between 8,0005,000 years ago. At the beginning of the Neolithic period in Europe, 8,0007,000 years ago, closely related groups of early farmers appeared in Germany, Hungary and Spain, different from indigenous hunter-gatherers, whereas Russia was inhabited by a distinctive population of hunter-gatherers with high affinity to a 24,000-year-old Siberian. By 6,0005,000 years ago, farmers throughout much of Europe had more hunter-gatherer ancestry than their predecessors, but in Russia, the Yamnaya steppe herders of this time were descended not only from the preceding eastern European hunter-gatherers, but also from a population of Near Eastern ancestry. Western and Eastern Europe came into contact 4,500 years ago, as the Late Neolithic Corded Ware people from Germany traced 75% of their ancestry to the Yamnaya, documenting a massive migration into the heartland of Europe from its eastern periphery. This steppe ancestry persisted in all sampled central Europeans until at least 3,000 years ago, and is ubiquitous in present-day Europeans. These results provide support for a steppe origin of at least some of the Indo-European languages of Europe.
Contact: Patrice Macaluso
Thursday, March 12, 2015
6:00 PM - 7:00 PM
Microbial Sciences Initiative (MSI) Seminar: P. Levin
Description: Title: Growth rate, metabolism and bacterial cell size
Speaker: Petra Levin (Washington University in St. Louis)
Location: HUCE Seminar Room 310 (24 Oxford St, 3rd Floor, Cambridge)
Host: Tom Bernhardt
Reception at 5:30PM, seminar at 6:00PM
Contact: Nora Millan Rivas
Wednesday, March 18, 2015
11:30 AM - 1:00 PM
Bioinformatics Seminar Series:Evolutionary couplings: causal relationships for discovery and design
Description: Speaker: Debora Marks , Harvard Medical School
Location: Stata Center 32-G575

There is a now major opportunity to link genomic sequence information to phenotype and to apply this to concrete engineering and health problems. Attributes of living systems are constrained in evolution. An alternative to the analysis of conserved attributes ('characters') is analysis of functional interactions ('couplings') that cause conservation. Collections of sequence homologs record the outcomes of millions of evolutionary experiments in which the protein evolves according to functional constraints. This record of evolutionary constraints can in principle be exploited for predictive and engineering purposes. My previous work demonstrated that sequence co-evolution in proteins in the form of amino acid pairwise co-variation across a protein family, given sufficiently diverse sequence information, can be used to fold proteins, to predict oligomerization, identify functional sites and determine protein interactions. I will present new aspects of this work including the theoretical foundation, how that can be improved and used to address critical open questions in biology such as protein plasticity, fibrils formation and the quantitative effect of genetic variation.
Contact: Patrice Macaluso
Thursday, March 19, 2015
3:00 PM - 4:00 PM
Distinguished Lecture Series: Regenerative medicine - a breakthrough way of thinking about disease and injury, using a process that can signal the body to rebuild itself
Description: Alan Russell, PhD, Highmark Distinguished Career Professor; Director, Disruptive Health Technology Institute, Carnegie Mellon University

Meltzer Auditorium, Mass Eye and Ear, 3rd floor, 243 Charles Street, Boston, MA 02114
Contact: Susan Cardoza
Friday, March 20, 2015
8:30 AM - 9:30 AM
Microbial Sciences Initiative (MSI) Chalktalk: C. Vidoudez
Description: Title: Deep Sea Metabolomics
Speaker: Charles Vidoudez (FAS-OEB)
Location: HUCE Seminar Room, Room 310 (24 Oxford St, 3rd Floor, Cambridge)
Host: Peter Girguis
Contact: Nora Millan Rivas
Tuesday, March 24, 2015
12:30 PM - 1:30 PM
An outer membrane lipoprotein detects envelope stress by monitoring β-barrel assembly
Description: Jean-Francois Collet, Universite catholique de Louvain
Hosted by Tom Bernhardt

Harvard Medical School, New Research Building - Room 1031, 77 Ave. Louis Pasteur
Contact: Jessica Conner
Friday, March 27, 2015
8:30 AM - 9:30 AM
Microbial Sciences Initiative (MSI) Seminar: L. Vandenberghe
Description: Title: Back to the future: Viruses and gene therapy
Speaker: Luk Vandenberghe (HMS-Ophthalmology)
Location: HUCE Seminar Room 310 (24 Oxford St, 3rd Floor, Cambridge)
Host: Michael Gilmore
Contact: Nora Millan Rivas
Friday, April 3, 2015
8:30 AM - 9:30 AM
Microbial Sciences Initiative (MSI) Chalktalk: A. Cantley
Description: Title: Chemical signals from bacteria and their effects on host development
Speaker: Alexandra Cantley (HMS-BCMP)
Location: HUCE Seminar Room 310 (24 Oxford St, 3rd Floor, Cambridge)
Host: Jon Clardy
Contact: Nora Millan Rivas
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